Cardiovascular profile of the calcium sensitizer EMD 57033 in open‐chest anaesthetized pigs with regionally stunned myocardium

Ca2+ sensitizers enhance systolic function, but may impair relaxation in vitro; these effects may differ in stunned and normal myocardium. We therefore studied the effect of EMD 57033 on systolic and diastolic function of normal and stunned porcine myocardium in vivo. Myocardial stunning by 15 min c...

Full description

Saved in:
Bibliographic Details
Published in:British journal of pharmacology 2000-04, Vol.129 (7), p.1413-1422
Main Authors: De Zeeuw, Sandra, Trines, Serge A I P, Krams, Rob, Verdouw, Pieter D, Duncker, Dirk J
Format: Article
Language:English
Subjects:
Adrenoceptor blockade
Anesthesia
Animals
Biological and medical sciences
Brain - metabolism
Ca2+ sensitization
Cardiac Surgical Procedures
Cardiotonic Agents - pharmacology
Cardiovascular system
Cardiovascular System - drug effects
Cardiovascular System - physiopathology
Catecholaminergic system
Diastole - drug effects
Diastole - physiology
diastolic function
end‐diastolic elastance
end‐systolic elastance
Female
Hemodynamics - drug effects
Liver - metabolism
Male
Medical sciences
Miscellaneous
Muscle, Skeletal - metabolism
myocardial relaxation
Myocardial Stunning - metabolism
Myocardial Stunning - physiopathology
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
nitric oxide
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
phosphodiesterase III inhibition
Quinolines - blood
Quinolines - pharmacokinetics
Quinolines - pharmacology
Stroke Volume - drug effects
Swine
Systole - drug effects
Systole - physiology
systolic shortening
Thiadiazines - blood
Thiadiazines - pharmacokinetics
Thiadiazines - pharmacology
Tissue Distribution
Vascular Resistance - drug effects
Ventricular Dysfunction, Left - physiopathology
Ventricular Pressure - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Ca2+ sensitizers enhance systolic function, but may impair relaxation in vitro; these effects may differ in stunned and normal myocardium. We therefore studied the effect of EMD 57033 on systolic and diastolic function of normal and stunned porcine myocardium in vivo. Myocardial stunning by 15 min coronary occlusion and 30 min reperfusion abolished systolic shortening (SS) (baseline 13±1%) and decreased end‐systolic elastance (Ees) from 67±7 to 47±5 mmHg mm−1 (both P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0703231