Role of A2A‐adenosine receptor activation for ATP‐mediated coronary vasodilation in guinea‐pig isolated heart

Adenosine‐5′‐triphosphate (ATP) and adenosine are potent coronary vasodilators. ATP is rapidly converted to adenosine by ectonucleotidases. We examined whether coronary vasodilation caused by exogenous ATP is mediated by P2 receptor activation or by A2A‐adenosine receptor activation. Effects of inte...

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Bibliographic Details
Published in:British journal of pharmacology 2000-07, Vol.130 (5), p.1065-1075
Main Authors: Erga, Knut Ståle, Seubert, Christoph N, Liang, Hui‐Xiu, Wu, Lin, Shryock, John C, Belardinelli, Luiz
Format: Article
Language:English
Subjects:
A2A‐receptors
adenosine
Adenosinic and purinergic receptors
AOPCP
ARL67156
ATP
Biological and medical sciences
Cell receptors
Cell structures and functions
coronary regulation
Fundamental and applied biological sciences. Psychology
Isolated heart
Molecular and cellular biology
P2‐agonists
vasodilation
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Summary:Adenosine‐5′‐triphosphate (ATP) and adenosine are potent coronary vasodilators. ATP is rapidly converted to adenosine by ectonucleotidases. We examined whether coronary vasodilation caused by exogenous ATP is mediated by P2 receptor activation or by A2A‐adenosine receptor activation. Effects of interventions on coronary conductance were determined by measuring coronary perfusion pressure in guinea‐pig isolated hearts perfused at a constant flow of 10 ml min−1. ATP and adenosine both caused sustained, concentration‐dependent increases of coronary conductance. Maximal responses to both agonists were equivalent. The values of pD2 (±s.e.mean) for ATP and adenosine were 6.68±0.04 and 7.06±0.05, respectively. Adenosine was significantly more potent than ATP (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0703386