Nedocromil sodium inhibits histamine‐induced itch and flare in human skin

This study was designed to test the hypothesis that nedocromil sodium inhibits sensory nerve function to reduce flare and itch in human skin. Nedocromil sodium (2%) or water (control) was introduced into the volar forearm skin of eight non‐atopic volunteers by iontophoresis (8 mC) and histamine (20 ...

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Bibliographic Details
Published in:British journal of pharmacology 2001-02, Vol.132 (3), p.613-616
Main Authors: Ahluwalia, Poonam, McGill, James I, Church, Martin K
Format: Article
Language:English
Subjects:
Adult
Anti-Inflammatory Agents - therapeutic use
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
cromones
Female
flare
Histamine
Histamine H1 Antagonists - pharmacology
Humans
Iontophoresis
itch
Male
Medical sciences
Nedocromil - therapeutic use
Nedocromil sodium
Nerve Tissue - metabolism
Pharmacology. Drug treatments
Pruritus - chemically induced
Pruritus - drug therapy
Regional Blood Flow - drug effects
skin
Skin Diseases - chemically induced
Skin Diseases - drug therapy
Special Reports
Treatment Outcome
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Summary:This study was designed to test the hypothesis that nedocromil sodium inhibits sensory nerve function to reduce flare and itch in human skin. Nedocromil sodium (2%) or water (control) was introduced into the volar forearm skin of eight non‐atopic volunteers by iontophoresis (8 mC) and histamine (20 μl of 1 μM and 300 nM) injected intradermally 10 min later at the same site. Itch was assessed on a visual analogue scale every 20 s for 5 min. Weal and flare areas and mean blood flux within the flare were assessed by scanning laser Doppler imaging at 10 min. The results showed that nedocromil sodium reduced itch scores, totalled over 5 min, by ∼74.0% (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0703852