Apocynin and 1400 W prevents airway hyperresponsiveness during allergic reactions in mice

The contribution of reactive nitrogen species to the development of airway hyperresponsiveness in a mouse model of allergic inflammation was investigated by the use of selective inhibitors of nitric oxide and superoxide formation. Sensitized mice, repeatedly challenged with ovalbumin showed a signif...

Full description

Saved in:
Bibliographic Details
Published in:British journal of pharmacology 2001-09, Vol.134 (2), p.434-440
Main Authors: Muijsers, Richard B R, Van Ark, Ingrid, Folkerts, Gert, Koster, Andries S, Van Oosterhout, Antoon J M, Postma, Dirkje S, Nijkamp, Frans P
Format: Article
Language:English
Subjects:
Acetophenones - pharmacology
Amidines - pharmacology
Animals
Antioxidants - pharmacology
asthma
Benzylamines - pharmacology
Biological and medical sciences
Bronchial Hyperreactivity - immunology
Bronchial Hyperreactivity - prevention & control
Bronchoalveolar Lavage Fluid - cytology
Chronic obstructive pulmonary disease, asthma
Disease Models, Animal
Enzyme Inhibitors - pharmacology
Eosinophils - cytology
Eosinophils - drug effects
hyperresponsiveness
Hypersensitivity - immunology
Immunoglobulin E - blood
Immunoglobulin E - drug effects
Immunohistochemistry
Interferon-gamma - drug effects
Interferon-gamma - metabolism
Interleukin-4 - metabolism
Interleukin-5 - metabolism
Lung - chemistry
Lung - drug effects
Male
Medical sciences
Mice
Mice, Inbred BALB C
Neutrophils - cytology
Neutrophils - drug effects
Nitric oxide
Nitric Oxide Synthase - antagonists & inhibitors
Ovalbumin - immunology
Pneumology
Specific Pathogen-Free Organisms
superoxide
Tyrosine - analogs & derivatives
Tyrosine - analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The contribution of reactive nitrogen species to the development of airway hyperresponsiveness in a mouse model of allergic inflammation was investigated by the use of selective inhibitors of nitric oxide and superoxide formation. Sensitized mice, repeatedly challenged with ovalbumin showed a significant (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0704235