Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats

This investigation reports the possible role of the endocannabinoid anandamide in modulating appetitive behaviour. Given that cannabinoids have been used clinically to stimulate appetite in HIV and cancer chemotherapy patients, there has been a renewed interest in the involvement of cannabinoids in...

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Bibliographic Details
Published in:British journal of pharmacology 2001-11, Vol.134 (6), p.1151-1154
Main Authors: Jamshidi, Nazila, Taylor, David A
Format: Article
Language:English
Subjects:
Anandamide
Animals
appetite
Appetite Stimulants - pharmacology
Arachidonic Acids - pharmacology
Biological and medical sciences
Cannabinoid Receptor Modulators
Cannabinoids - antagonists & inhibitors
Eating - drug effects
Endocannabinoids
Male
Medical sciences
Miscellaneous
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Piperidines - pharmacology
Polyunsaturated Alkamides
Pyrazoles - pharmacology
Rats
Rats, Wistar
Special Report
SR 141716
Ventromedial Hypothalamic Nucleus - drug effects
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Summary:This investigation reports the possible role of the endocannabinoid anandamide in modulating appetitive behaviour. Given that cannabinoids have been used clinically to stimulate appetite in HIV and cancer chemotherapy patients, there has been a renewed interest in the involvement of cannabinoids in appetite modulation. This is the first report on the administration of anandamide into the ventromedial hypothalamus. Pre‐satiated rats received an intrahypothalamic injection of anandamide (50 ng 0.5 μl−1) followed by measurement of food intake at 3 h post injection. Administration of anandamide induced significant hyperphagia. Pretreatment with the selective CB1 cannabinoid antagonist SR 141716 (30 μg 0.5 μl−1), 30 min prior to anandamide injection resulted in an attenuation of the anandamide‐induced hyperphagia (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0704379