CB1 cannabinoid receptor antagonism promotes remodeling and cannabinoid treatment prevents endothelial dysfunction and hypotension in rats with myocardial infarction

To study the long‐term effects of altered cannabinoid receptor activity on myocardial and vascular function, Wistar rats were treated with the selective CB1 antagonist AM‐251 (0.5 mg kg−1 d−1), the potent synthetic cannabinoid HU‐210 (50 μg kg−1 d−1) or vehicle for 12 weeks after coronary artery lig...

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Bibliographic Details
Published in:British journal of pharmacology 2003-04, Vol.138 (7), p.1251-1258
Main Authors: Wagner, Jens A, Hu, Kai, Karcher, Jan, Bauersachs, Johann, Schäfer, Andreas, Laser, Martin, Han, Hong, Ertl, Georg
Format: Article
Language:English
Subjects:
AM‐251
anandamide
cannabinoid receptors
endothelial function
Heart failure
hemodynamics
HU‐210
myocardial infarction
remodeling
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Summary:To study the long‐term effects of altered cannabinoid receptor activity on myocardial and vascular function, Wistar rats were treated with the selective CB1 antagonist AM‐251 (0.5 mg kg−1 d−1), the potent synthetic cannabinoid HU‐210 (50 μg kg−1 d−1) or vehicle for 12 weeks after coronary artery ligation or sham operation. AM‐251 further reduced the pressure‐generating capacity, shifted the pressure volume curve to the right (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0705156