Sildenafil (Viagra) reduces arrhythmia severity during ischaemia 24 h after oral administration in dogs

Sildenafil (Viagra) prolongs repolarisation in cardiac muscle, an effect that could lead to ventricular fibrillation (VF). Sildenafil (2 mg kg−1) was given by mouth to 12 mongrel dogs and, 24 h later, these dogs were anaesthetised, thoracotomised and subjected to a 25 min occlusion of the anterior d...

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Bibliographic Details
Published in:British journal of pharmacology 2004-02, Vol.141 (4), p.549-551
Main Authors: Nagy, Orsolya, Hajnal, Ágnes, Parratt, James R, Végh, Ágnes
Format: Article
Language:English
Subjects:
Animals
Anti-Arrhythmia Agents
Arrhythmias, Cardiac - etiology
Arrhythmias, Cardiac - prevention & control
Biological and medical sciences
Cardiac dysrhythmias
Cardiology. Vascular system
Coronary heart disease
Coronary Vessels - physiology
delayed preconditioning
Dogs
Electrocardiography
Heart
Hemodynamics - drug effects
Hemodynamics - physiology
Medical sciences
myocardial ischaemia
Myocardial Reperfusion Injury - complications
Phosphodiesterase Inhibitors - pharmacology
Piperazines - pharmacology
Purines
Sildenafil
Sildenafil Citrate
Special Report
Stroke Volume - drug effects
Sulfones
Tachycardia, Ventricular - physiopathology
Tachycardia, Ventricular - prevention & control
ventricular arrhythmias
Ventricular Dysfunction, Left - physiopathology
Ventricular Dysfunction, Left - prevention & control
Ventricular Fibrillation - physiopathology
Ventricular Fibrillation - prevention & control
Ventricular Premature Complexes - physiopathology
Ventricular Premature Complexes - prevention & control
viagra
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Summary:Sildenafil (Viagra) prolongs repolarisation in cardiac muscle, an effect that could lead to ventricular fibrillation (VF). Sildenafil (2 mg kg−1) was given by mouth to 12 mongrel dogs and, 24 h later, these dogs were anaesthetised, thoracotomised and subjected to a 25 min occlusion of the anterior descending coronary artery. Haemodynamic parameters were similar in this and the control group, but there were fewer and less serious ventricular arrhythmias during occlusion in the sildenafil group (VF 17 vs 60%; ventricular premature beats 140±52 vs 437±127% and episodes of ventricular tachycardia 4.0±3.2 vs 19.3±7.7%, all P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0705658