Interspecies cross-reactive determinants of thyroglobulin recognized by autoantibodies

In this study, we have attempted to characterize the epitopes of thyroglobulin (Tg) recognized by autoantibodies. Anti-autologous Tg from the serum reacted with other Tg from whales, pigs, cows, chickens and rats as well as with human Tg, thereby indicating that human Tg share epitopes recognized by...

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Bibliographic Details
Published in:Clinical and experimental immunology 1985-07, Vol.61 (1), p.44-48
Main Authors: KOHNO, Y, NAKAJIMA, H, TARUTANI, O
Format: Article
Language:English
Subjects:
Adolescent
Adult
Animals
Antigen-Antibody Reactions
Autoantibodies - immunology
Binding, Competitive
Biological and medical sciences
Cattle
Chickens
Child
Cross Reactions
Endocrinopathies
Epitopes - analysis
Graves Disease - immunology
Humans
Medical sciences
Mice
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Rats
Swine
Thyroglobulin - immunology
Thyroid. Thyroid axis (diseases)
Thyroiditis - immunology
Whales
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Summary:In this study, we have attempted to characterize the epitopes of thyroglobulin (Tg) recognized by autoantibodies. Anti-autologous Tg from the serum reacted with other Tg from whales, pigs, cows, chickens and rats as well as with human Tg, thereby indicating that human Tg share epitopes recognized by autoantibodies with Tg from various animal species.
ISSN:0009-9104
1365-2249