Eosinophilic lung disease: immunological studies of blood and alveolar eosinophils

Five patients with eosinophilic lung diseases and blood hypereosinophilia (PIE syndrome) were investigated clinically and by bronchoalveolar lavage (BAL). Comparative studies on blood and alveolar eosinophils were carried out after purification and selection of eosinophil subpopulations according to...

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Bibliographic Details
Published in:Clinical and experimental immunology 1986, Vol.63 (1), p.249-257
Main Authors: PRIN, L, CAPRON, O, GOSSET, P, WALLAERT, B, KUSNIERZ, J. P, BLETRY, O, TONNEL, A. B, CAPRON, A
Format: Article
Language:English
Subjects:
Adult
Allergic diseases
Biological and medical sciences
Eosinophilia - immunology
Eosinophils - analysis
Eosinophils - immunology
Female
Humans
Immunoglobulin E - analysis
Immunopathology
Leukocyte Count
Male
Medical sciences
Middle Aged
Pulmonary Alveoli - immunology
Pulmonary Eosinophilia - immunology
Receptors, Antigen, B-Cell - analysis
Respiratory and ent allergic diseases
Therapeutic Irrigation
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Summary:Five patients with eosinophilic lung diseases and blood hypereosinophilia (PIE syndrome) were investigated clinically and by bronchoalveolar lavage (BAL). Comparative studies on blood and alveolar eosinophils were carried out after purification and selection of eosinophil subpopulations according to their density. A predominant 'hypodense' alveolar eosinophil population was found in BAL fluids of active chronic eosinophilic pneumonia (CEP). In addition, supernatants of alveolar macrophages obtained from CEP are able to enhance spontaneously the generation of eosinophil oxygen metabolites. Such eosinophil stimulation emphasizes a probable tissue cell cooperation. In addition, BAL permitted the study of membrane immunological markers on eosinophilic inflammatory cells endowed with migratory properties. An increase in eosinophils carrying surface IgE was demonstrated in alveolar cells from PIE Syndrome particularly with hypodense eosinophils from CEP patients. Although no specific stimulus is known at the present time, this work underlines the potential implication of IgE-mediated hypersensitivity processes in the pathogenesis of eosinophilic lung diseases.
ISSN:0009-9104
1365-2249