THE POTENTIATION OF RADIATION EFFECTS WITH 5-FLUORO-URACIL

A preliminary study of the response of various inoperable malignant diseases to simultaneously administered 5-fluoro-uracil and orthovolt x-ray was performed. The 5-fluoro-uracil was given intravenously at a relatively nontoxic dosage level. The x-ray tumor dose was limited to 2,000 roentgens in eve...

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Bibliographic Details
Published in:California medicine 1960-11, Vol.93 (5), p.288-290
Main Authors: Foye, Laurance V., Willett, Forrest M., Hall, Byron, Roth, Merall
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell
Esophagitis
Fluorouracil
Humans
Lung
Lung Neoplasms
Male
Middle Aged
Neoplasms - therapy
Radiotherapy
Radiotherapy Dosage
Uracil - analogs & derivatives
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Summary:A preliminary study of the response of various inoperable malignant diseases to simultaneously administered 5-fluoro-uracil and orthovolt x-ray was performed. The 5-fluoro-uracil was given intravenously at a relatively nontoxic dosage level. The x-ray tumor dose was limited to 2,000 roentgens in every patient. Pronounced and rapid tumor regression occurred in 12 of 18 evaluable patients. Significant objective response was obtained in each of eight patients with epidermoid carcinoma of the lung. Toxicity occurred in half of the patients, manifested by pharyngitis, esophagitis, proctitis, leukopenia and thrombocytopenia. Images
ISSN:0008-1264
2380-9949