Modification of the graft-versus-host syndrome by anti-lymphocyte serum treatment of the host

The effect of administering anti-lymphocyte serum (ALS) to the F 1 hybrid recipient at various time intervals before and after the injection of parental donor cells has been investigated. The graft- versus -host (GVH) response can be completely inhibited by a single ALS injection given a short while...

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Bibliographic Details
Published in:Clinical and experimental immunology 1968-10, Vol.3 (8), p.801-808
Main Authors: Boak, J L, Dagher, R K, Corson, J M, Wilson, R E
Format: Article
Language:English
Subjects:
Animals
Antilymphocyte Serum - pharmacology
Carbon
Graft vs Host Disease - immunology
Immune Sera - pharmacology
Injections, Intraperitoneal
Lymph Nodes - immunology
Lymphocytes - drug effects
Lymphocytes - immunology
Male
Mice
Organ Size
Phagocytosis
Rabbits
Spleen - anatomy & histology
Spleen - immunology
Time Factors
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Summary:The effect of administering anti-lymphocyte serum (ALS) to the F 1 hybrid recipient at various time intervals before and after the injection of parental donor cells has been investigated. The graft- versus -host (GVH) response can be completely inhibited by a single ALS injection given a short while before the injection of parental cells. ALS injected after the injection of donor cells fails to influence the GVH response. It is considered that these studies confirm the view that ALS acts mainly on circulating lymphocytes and that a single ALS injection does not influence lymphocytes resident in spleen and lymph nodes.
ISSN:0009-9104
1365-2249