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Trial of Chloramphenicol for Meningitis in Northern Savanna of Africa
In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduce...
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| Published in: | BMJ 1973-08, Vol.3 (5876), p.379-381 |
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| Main Authors: | , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 381 |
| container_issue | 5876 |
| container_start_page | 379 |
| container_title | BMJ |
| container_volume | 3 |
| creator | Whittle, H. C. Davidson, N. McD Greenwood, B. M. Warrell, D. A. Tomkins, A. Tugwell, P. Zalin, A. Bryceson, A. D. M. Parry, E. H. O. Brueton, M. Duggan, M. Rajković, A. D. |
| description | In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment. It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant. |
| doi_str_mv | 10.1136/bmj.3.5876.379 |
| format | article |
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C. ; Davidson, N. McD ; Greenwood, B. M. ; Warrell, D. A. ; Tomkins, A. ; Tugwell, P. ; Zalin, A. ; Bryceson, A. D. M. ; Parry, E. H. O. ; Brueton, M. ; Duggan, M. ; Rajković, A. D.</creator><creatorcontrib>Whittle, H. C. ; Davidson, N. McD ; Greenwood, B. M. ; Warrell, D. A. ; Tomkins, A. ; Tugwell, P. ; Zalin, A. ; Bryceson, A. D. M. ; Parry, E. H. O. ; Brueton, M. ; Duggan, M. ; Rajković, A. D.</creatorcontrib><description>In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment. It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant.</description><identifier>ISSN: 0007-1447</identifier><identifier>ISSN: 0959-8138</identifier><identifier>EISSN: 1468-5833</identifier><identifier>DOI: 10.1136/bmj.3.5876.379</identifier><identifier>PMID: 4199744</identifier><language>eng</language><publisher>England: British Medical Journal Publishing Group</publisher><subject>Administration, Oral ; Adults ; Age groups ; Antibiotics ; Cerebrospinal Fluid - microbiology ; Child ; Child, Preschool ; Children ; Chloramphenicol - administration & dosage ; Chloramphenicol - therapeutic use ; Clinical Trials as Topic ; Dosage ; Dosage forms ; Epidemics ; Female ; Haemophilus meningitis ; Hemagglutination Tests ; Humans ; Infant ; Injections, Intramuscular ; Male ; Meningitis, Meningococcal - drug therapy ; Meningitis, Meningococcal - immunology ; Meningococcal meningitis ; Neisseria meningitidis - isolation & purification ; Nigeria ; Papers and Originals ; Penicillin ; Penicillin Resistance ; Penicillins - therapeutic use ; Sulfonamides - therapeutic use</subject><ispartof>BMJ, 1973-08, Vol.3 (5876), p.379-381</ispartof><rights>Copyright 1973 British Medical Journal</rights><rights>Copyright BMJ Publishing Group LTD Aug 18, 1973</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b507t-3fce555af1ba1ab19798e2685ebca1aa437b23f0fa8d704e36445d79cc9a71d83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1586699/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1586699/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,3193,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4199744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whittle, H. C.</creatorcontrib><creatorcontrib>Davidson, N. McD</creatorcontrib><creatorcontrib>Greenwood, B. M.</creatorcontrib><creatorcontrib>Warrell, D. A.</creatorcontrib><creatorcontrib>Tomkins, A.</creatorcontrib><creatorcontrib>Tugwell, P.</creatorcontrib><creatorcontrib>Zalin, A.</creatorcontrib><creatorcontrib>Bryceson, A. D. M.</creatorcontrib><creatorcontrib>Parry, E. H. O.</creatorcontrib><creatorcontrib>Brueton, M.</creatorcontrib><creatorcontrib>Duggan, M.</creatorcontrib><creatorcontrib>Rajković, A. D.</creatorcontrib><title>Trial of Chloramphenicol for Meningitis in Northern Savanna of Africa</title><title>BMJ</title><addtitle>Br Med J</addtitle><description>In a controlled trial chloramphenicol proved as effective and much cheaper than penicillin for the treatment of group A meningococcal meningitis in Zaria, Nigeria. A short course of five days cured most patients. Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment. It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant.</description><subject>Administration, Oral</subject><subject>Adults</subject><subject>Age groups</subject><subject>Antibiotics</subject><subject>Cerebrospinal Fluid - microbiology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Chloramphenicol - administration & dosage</subject><subject>Chloramphenicol - therapeutic use</subject><subject>Clinical Trials as Topic</subject><subject>Dosage</subject><subject>Dosage forms</subject><subject>Epidemics</subject><subject>Female</subject><subject>Haemophilus meningitis</subject><subject>Hemagglutination Tests</subject><subject>Humans</subject><subject>Infant</subject><subject>Injections, Intramuscular</subject><subject>Male</subject><subject>Meningitis, Meningococcal - drug therapy</subject><subject>Meningitis, Meningococcal - immunology</subject><subject>Meningococcal meningitis</subject><subject>Neisseria meningitidis - isolation & purification</subject><subject>Nigeria</subject><subject>Papers and Originals</subject><subject>Penicillin</subject><subject>Penicillin Resistance</subject><subject>Penicillins - therapeutic use</subject><subject>Sulfonamides - therapeutic use</subject><issn>0007-1447</issn><issn>0959-8138</issn><issn>1468-5833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1973</creationdate><recordtype>article</recordtype><recordid>eNqFUUlrGzEYFaEhNWmuuRUGCoUeZqp9uRSCm6WQpAenvQqNrInlzkiONA7tv48GG3e59KTlLd_7eACcI9ggRPjHdlg3pGFS8IYIdQRmiHJZM0nIKzCDEIoaUSpeg7Oc1-WJiZCK0xNwQpFSgtIZuHxI3vRV7Kr5qo_JDJuVC97Gvupiqu7KPTz60efKh-o-pnHlUqgW5tmEYCbVRZe8NW_AcWf67M725yn4dnX5ML-pb79ef5lf3NYtg2KsSWcdY8x0qDXItEgJJR3mkrnWlg9DiWgx6WBn5FJA6ginlC2FslYZgZaSnIJPO9_Nth3c0rowJtPrTfKDSb90NF7_jQS_0o_xWSMmOVeqGLzfG6T4tHV51IPP1vW9CS5us5YYEsbQNOndP8R13KZQltNICI4g5ogVVrNj2RRzTq47REFQTw3p0pAmempIl4aK4O2fCxzo-z5-4-s8xnSAMaO4jJz09Q73eXQ_D7hJPzQXRDB9_32uF_T6M-b4Si8K_8OOP-X4T7YXgwayFg</recordid><startdate>19730818</startdate><enddate>19730818</enddate><creator>Whittle, H. 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Adults and older children were soon able to take chloramphenicol by mouth, which reduced the cost and simplified treatment. It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant.</abstract><cop>England</cop><pub>British Medical Journal Publishing Group</pub><pmid>4199744</pmid><doi>10.1136/bmj.3.5876.379</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1447 |
| ispartof | BMJ, 1973-08, Vol.3 (5876), p.379-381 |
| issn | 0007-1447 0959-8138 1468-5833 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1586699 |
| source | BMJ; PubMed Central |
| subjects | Administration, Oral Adults Age groups Antibiotics Cerebrospinal Fluid - microbiology Child Child, Preschool Children Chloramphenicol - administration & dosage Chloramphenicol - therapeutic use Clinical Trials as Topic Dosage Dosage forms Epidemics Female Haemophilus meningitis Hemagglutination Tests Humans Infant Injections, Intramuscular Male Meningitis, Meningococcal - drug therapy Meningitis, Meningococcal - immunology Meningococcal meningitis Neisseria meningitidis - isolation & purification Nigeria Papers and Originals Penicillin Penicillin Resistance Penicillins - therapeutic use Sulfonamides - therapeutic use |
| title | Trial of Chloramphenicol for Meningitis in Northern Savanna of Africa |
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