Primary Acquired Sideroblastic Anaemia: Response to Treatment with Pyridoxal-5-Phosphate

A 72-year-old woman with primary sideroblastic anaemia showed no response to treatment with pyridoxine. When she was given pyridoxal-5-phosphate there was a prompt reticulocyte response and sustained symptomatic improvement with satisfactory control of the anaemia.

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Bibliographic Details
Published in:BMJ 1973-02, Vol.1 (5850), p.389-390
Main Authors: Mason, D. Y., Emerson, Pauline M.
Format: Article
Language:English
Subjects:
Aged
Anemia
Anemia, Sideroblastic - drug therapy
Ascorbic Acid - therapeutic use
Blood
Blood plasma
Blood transfusion
Bone marrow
Dosage
Erythroid progenitor cells
Female
Folic Acid - therapeutic use
Hemoglobinometry
Humans
Papers and Originals
Phosphates
Pyridoxal Phosphate - therapeutic use
Pyridoxine - therapeutic use
Reticulocytes
Sideroblastic anemia
Stem cells
Tryptophan - therapeutic use
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Description
Summary:A 72-year-old woman with primary sideroblastic anaemia showed no response to treatment with pyridoxine. When she was given pyridoxal-5-phosphate there was a prompt reticulocyte response and sustained symptomatic improvement with satisfactory control of the anaemia.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.5850.389