Significance of Perfusate Lactic Acidosis in Cadaveric Renal Transplantation

Thirty-two human cadaver kidneys were assessed by continuous perfusion before transplantation. Altogether, 26 were transplanted. Ten kidneys functioned immediately, of which nine had excellent renal function at three months. Sixteen had delayed onset of function, of these only five had excellent fun...

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Bibliographic Details
Published in:BMJ 1973-02, Vol.1 (5850), p.391-395
Main Authors: Johnson, R. W. G., Anderson, Marilyn, Taylor, R. M. R., Swinney, John
Format: Article
Language:English
Subjects:
Acidosis
Cadaver
Carbon Dioxide - blood
Cold Temperature
Creatinine - metabolism
Dialysis
Hot Temperature
Humans
Hydrogen-Ion Concentration
Ice
Kidney - enzymology
Kidney Function Tests
Kidney Transplantation
Kidneys
L-Lactate Dehydrogenase - metabolism
Lactates
Lactates - metabolism
Lactic acidosis
Papers and Originals
Perfusion
Physical trauma
Preliminary Communications
Storage time
Time Factors
Tissue Preservation
Transplantation
Transplantation, Homologous
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Summary:Thirty-two human cadaver kidneys were assessed by continuous perfusion before transplantation. Altogether, 26 were transplanted. Ten kidneys functioned immediately, of which nine had excellent renal function at three months. Sixteen had delayed onset of function, of these only five had excellent function at three months. There was no difference in warm ischaemic interval between the two groups or in ice storage time. The immediate function group, however, were perfused for twice as long as the delayed function group. The two groups could not be separated on donor history, but they could be precisely separated during perfusion by measuring lactic acidosis and lactic acid dehydrogenase (LDH). The biggest single difference between the groups was in terms of donor preparation.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.5850.391