Immunological Studies in Ugandan Patients with Hepatocellular Carcinoma

Immunological studies were performed on Ugandan patients with hepatocellular carcinoma to test the hypothesis that the high rate of persistence of hepatitis-associated antigen in these patients is the result of defects in host immune response. The responses to 1-chloro-2,4-dinitrobenzene sensitizati...

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Bibliographic Details
Published in:BMJ 1973-01, Vol.1 (5844), p.16-19
Main Authors: Primack, Aron, Vogel, Charles L., Barker, Lewellys F.
Format: Article
Language:English
Subjects:
Adult
Agammaglobulinemia - immunology
Antibodies
Antibody Formation
Antigens
Carcinoma, Hepatocellular - immunology
Cirrhosis
Deficiency diseases
Female
Hepatitis B Antigens
Hepatocellular carcinoma
Humans
Immunity, Cellular
Immunoglobulins
Immunoglobulins - analysis
Infections
Internal medicine
Liver Cirrhosis - immunology
Liver Neoplasms - immunology
Male
Nitrobenzenes
Papers and Originals
Radioimmunoassay
Skin Tests
Transplantation immunology
Uganda
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Summary:Immunological studies were performed on Ugandan patients with hepatocellular carcinoma to test the hypothesis that the high rate of persistence of hepatitis-associated antigen in these patients is the result of defects in host immune response. The responses to 1-chloro-2,4-dinitrobenzene sensitization and to a battery of recall skin test antigens were normal, as was the humoral antibody response to tularaemia antigen. Neither hypogammaglobulinaemia nor specific immunoglobulin deficiencies were found. Thus it appears unlikely that generalized defects in host immune responses can account for the high incidence of persistent hepatitis B virus infection found in Ugandan patients with hepatocellular carcinoma.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.5844.16