Familial Occurrence of Persistent Müllerian Structures in Otherwise Normal Males

Eight cases of males with persistent Müllerian structures are reported in four pairs of unrelated siblings. A genetically inherited failure to produce or to respond to the Müllerian-inhibiting substance elaborated by the fetal testis is postulated.

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Bibliographic Details
Published in:BMJ 1973-03, Vol.1 (5856), p.771-773
Main Authors: Brook, C. G. D., Wagner, H., Zachmann, M., Prader, A., Armendares, S., Frenk, S., Aleman, P., Najjar, S. S., Slim, M. S., Genton, N., Bozic, C.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Child
Child, Preschool
Cryptorchidism
Cryptorchidism - pathology
Disorders of Sex Development - complications
Disorders of Sex Development - genetics
Fallopian tubes
Fallopian Tubes - abnormalities
Family structure
Female
Genitalia, Male - abnormalities
Genitalia, Male - embryology
Genitalia, Male - growth & development
Gonads
Histology
Humans
Inguinal hernia
Male
Mullerian Ducts - abnormalities
Papers and Originals
Penis
Siblings
Testes
Testicular Neoplasms - etiology
Testis - pathology
Uterus
Uterus - abnormalities
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Description
Summary:Eight cases of males with persistent Müllerian structures are reported in four pairs of unrelated siblings. A genetically inherited failure to produce or to respond to the Müllerian-inhibiting substance elaborated by the fetal testis is postulated.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.5856.771