Effect of Fenfluramine on Human Growth Hormone Release

In order to investigate the effect of fenfluramine on hormonal and metabolic changes with exercise, five normal volunteers have been studied during and after 20 minutes of steady exercise on a bicycle ergometer after injection of fenfluramine (20 mg intravenously). Fenfluramine abolished the rise of...

Full description

Saved in:
Bibliographic Details
Published in:BMJ 1973-05, Vol.2 (5862), p.329-332
Main Authors: Sulaiman, W. R., Johnson, R. H.
Format: Article
Language:English
Subjects:
Acromegaly
Acromegaly - drug therapy
Adult
Aged
Blood Glucose
Blood plasma
Female
Fenfluramine - pharmacology
Fenfluramine - therapeutic use
Growth Hormone - metabolism
Hormones
Humans
Hypothalamus
Injections, Intravenous
Insulin
Insulin - blood
Ketone bodies
Ketone Bodies - blood
Lactates
Lactates - blood
Male
Medical journals
Middle Aged
Nonesterified fatty acids
Papers and Originals
Physical Exertion
Pyruvates - blood
Secretory Rate - drug effects
Volunteerism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In order to investigate the effect of fenfluramine on hormonal and metabolic changes with exercise, five normal volunteers have been studied during and after 20 minutes of steady exercise on a bicycle ergometer after injection of fenfluramine (20 mg intravenously). Fenfluramine abolished the rise of plasma human growth hormone (HGH) which occurred in control investigations. Fenfluramine also affected plasma insulin, blood glucose, and ketone body levels. The acute effect of fenfluramine on the release of growth hormone was examined further by studying its effect in patients with acromegaly. A marked depression of growth hormone occurred both at rest and with exercise. These observations indicate that fenfluramine has a direct effect on pathways controlling growth hormone release. We also suggest that this action may have practical use in the medical treatment of acromegaly.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5862.329