Effects of Clonidine Withdrawal: Possible Mechanisms and Suggestions for Management

A severe rebound rise in blood pressure with agitation and insomnia had been noted in five patients when they had previously ceased clonidine (Catapres) This has been shown to be reproducible in these patients and to be associated with a significant increase in urinary catecholamine excretion. The b...

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Bibliographic Details
Published in:BMJ 1973-04, Vol.2 (5860), p.209-211
Main Authors: Hunyor, Stephen N., Hansson, Lennart, Harrison, Timothy S., Hoobler, Sibley W.
Format: Article
Language:English
Subjects:
Adrenergics
Blood plasma
Blood Pressure
Catecholamines
Catecholamines - blood
Catecholamines - urine
Clonidine - adverse effects
Clonidine - therapeutic use
Dosage
Epinephrine - blood
Epinephrine - urine
Excretion
Heart Rate
Humans
Hypertension
Hypertension - drug therapy
Hypertension - etiology
Injections, Intravenous
Norepinephrine
Norepinephrine - blood
Norepinephrine - urine
Papers and Originals
Phentolamine - administration & dosage
Phentolamine - therapeutic use
Propranolol - administration & dosage
Propranolol - therapeutic use
Sleep Initiation and Maintenance Disorders - etiology
Substance Withdrawal Syndrome - drug therapy
Urine
Citations: Items that cite this one
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Summary:A severe rebound rise in blood pressure with agitation and insomnia had been noted in five patients when they had previously ceased clonidine (Catapres) This has been shown to be reproducible in these patients and to be associated with a significant increase in urinary catecholamine excretion. The blood pressure can be controlled and the symptoms alleviated promptly by alpha and beta adrenergic receptor blockade using intravenous phentolamine and propranolol.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5860.209