Bone mineral accretion rate and calcium intake in preterm infants

Thirty six preterm infants (20 boys) of 25 to 32 weeks' gestation were observed from birth to around 40 weeks' postconception. When oral feeding became possible, nine received mother's own breast milk (group B), 15 formula feed (group F), and 12 formula feed supplemented with calcium...

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Bibliographic Details
Published in:Archives of disease in childhood 1989-07, Vol.64 (7 Spec No), p.910-918
Main Authors: Horsman, A, Ryan, S W, Congdon, P J, Truscott, J G, Simpson, M
Format: Article
Language:English
Subjects:
Accretion
Bone and Bones - metabolism
Bone Diseases, Metabolic - prevention & control
Breast milk
Calcium
Calcium Gluconate - therapeutic use
Calcium, Dietary - administration & dosage
Female
Growth - drug effects
Humans
Infant Nutritional Physiological Phenomena
Infant, Newborn
Infant, Premature, Diseases - prevention & control
Infants
Male
Minerals - metabolism
Phosphorus - administration & dosage
Pregnancy
Premature Infants
Vitamin D
Young Children
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Summary:Thirty six preterm infants (20 boys) of 25 to 32 weeks' gestation were observed from birth to around 40 weeks' postconception. When oral feeding became possible, nine received mother's own breast milk (group B), 15 formula feed (group F), and 12 formula feed supplemented with calcium (5 ml 10% calcium gluconate/100 ml feed) and phosphorus (0.5 ml 17% potassium phosphate similarly) (group S). All received a daily supplement of 400 IU vitamin D. Intakes of calcium, phosphorus, vitamin D, energy, and fluid volume were recorded. When oral feeding started, and near 40 weeks' postconception, bone mineral content of the forearm was measured by photon absorptiometry; weight and crown-heel length were also measured. After logarithmic transformation of the measurements, there were no significant intergroup differences between the mean rate constants for weight or crown-heel length describing growth during the observation period. The mean rate constant for mineral accretion (M) was significantly higher in group S than in both the others. Pooling all data, M was significantly correlated with calcium intake but not with any other variable. Mineral supplementation of feed can reduce but not cure osteopenia of prematurity.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.64.7_Spec_No.910