Beta-adrenoceptor-blocking drugs and blood sugar control in diabetes mellitus

The effects on diabetic control of the relative cardioselective beta-blocker metoprolol and the non-selective drug propranolol were compared in 20 hypertensive diabetic patients receiving diet alone or diet and oral hypoglycaemic agents. Each drug was given for one month in a double-blind, cross-ove...

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Bibliographic Details
Published in:BMJ 1979-01, Vol.1 (6157), p.159-161
Main Authors: Wright, A D, Barber, S G, Kendall, M J, Poole, P H
Format: Article
Language:English
Subjects:
Adult
Aged
Antihypertensives
Blood
Blood Glucose - metabolism
Cardiovascular agents
Clinical Trials as Topic
Diabetes
Diabetes Complications
Diabetes mellitus
Diabetes Mellitus - blood
Double-Blind Method
Fasting
Female
Humans
Hypertension - complications
Hypertension - drug therapy
Insulin
Male
Metoprolol - pharmacology
Metoprolol - therapeutic use
Middle Aged
Placebos
Propanolamines - pharmacology
Propranolol - pharmacology
Propranolol - therapeutic use
Sugars
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Summary:The effects on diabetic control of the relative cardioselective beta-blocker metoprolol and the non-selective drug propranolol were compared in 20 hypertensive diabetic patients receiving diet alone or diet and oral hypoglycaemic agents. Each drug was given for one month in a double-blind, cross-over study. Fasting, noon, and mid-afternoon blood sugar concentrations rose by 1.0-1.5 mmol/l (18-27 mg/100 ml). The rise with propranolol was not significantly greater than with metoprolol. In a few patients the rise was clinically important. The small overall change observed in diabetic control should not deter the use of beta-blockers in non-insulin-dependent diabetics, provided control is carefully monitored at the onset of treatment.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.6157.159