Plasma arginine vasopressin concentrations and antidiuretic action of carbamazepine

Twelve subjects given therapeutic doses of carbamazepine showed no change in their plasma electrolyte concentrations. Ten of the 12 had abnormal water metabolism, however, their ability to excrete water loads being decreased. Plasma arginine vasopressin (AVP) concentrations fell while the subjects w...

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Bibliographic Details
Published in:BMJ 1978-06, Vol.1 (6125), p.1445-1447
Main Authors: Stephens, W P, Coe, J Y, Baylis, P H
Format: Article
Language:English
Subjects:
Adult
Arginine Vasopressin - blood
Blood plasma
Carbamazepine - adverse effects
Carbamazepine - pharmacology
Diuresis
Diuresis - drug effects
Electrolytes
Female
Hormones
Humans
Load tests
Male
Medical journals
Sodium
Sodium - blood
Urine
Vasopressins - analogs & derivatives
Water - metabolism
Water deprivation
Water intoxication
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Summary:Twelve subjects given therapeutic doses of carbamazepine showed no change in their plasma electrolyte concentrations. Ten of the 12 had abnormal water metabolism, however, their ability to excrete water loads being decreased. Plasma arginine vasopressin (AVP) concentrations fell while the subjects were taking the drug, indicating that the mechanism is unlikely to be increased secretion of antidiuretic hormone. We suggest that the water-retaining property of carbamazepine is a physiological effect of the drug, mediated by increased renal sensitivity to normal plasma concentrations of AVP and resetting of osmoreceptors.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.6125.1445