Hodgkin's Disease in Patients with Previous Infectious Mononucleosis: 30 Years' Experience

Seventeen out of 17,073 people in Denmark who had had a positive reaction to a Paul-Bunnell test between the years 1940 and 1969 developed Hodgkin's disease after an interval of at least 12 months. This number was significantly (P < 0·0002) greater than the expected number of two women and f...

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Bibliographic Details
Published in:BMJ 1974-05, Vol.2 (5913), p.253-256
Main Authors: Rosdahl, Nils, Larsen, S. Olesen, Clemmesen, J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Antibodies, Heterophile - analysis
Cancer
Child
Child, Preschool
Denmark
Disease risk
Etiology
Female
Hemagglutination Tests
Hodgkin disease
Hodgkin Disease - complications
Hodgkin Disease - epidemiology
Hodgkin Disease - immunology
Human herpesvirus 4
Humans
Infectious diseases
Infectious mononucleosis
Infectious Mononucleosis - complications
Infectious Mononucleosis - epidemiology
Infectious Mononucleosis - immunology
Kidneys
Leukemia
Male
Medical Records
Middle Aged
Papers and Originals
Population Surveillance
Sex Factors
Single status
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Summary:Seventeen out of 17,073 people in Denmark who had had a positive reaction to a Paul-Bunnell test between the years 1940 and 1969 developed Hodgkin's disease after an interval of at least 12 months. This number was significantly (P < 0·0002) greater than the expected number of two women and four men. Sixteen of those developing Hodgkin's disease were men. Case records, which were available for 12 of them, confirmed that they had had infectious mononucleosis. The number of cases of leukaemia that developed in the sample population was no greater than expected.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5913.253