Physiological Distribution of Digoxin in Human Heart

Using the recipient's human heart removed at cardiac transplantation, the distribution of digoxin at both the cellular and subcellular level has been studied. In the presence of diffuse histological myocardial abnormalities tissue digoxin is decreased, but the subcellular distribution, presumab...

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Bibliographic Details
Published in:BMJ 1974-12, Vol.4 (5947), p.733-736
Main Authors: Coltart, D. John, Güllner, Hans Georg, Billingham, Margaret, Goldman, Robert H., Stinson, Edward B., Kalman, Sumner M., Harrison, Donald C.
Format: Article
Language:English
Subjects:
Adenosine triphosphatases
Adenosine Triphosphatases - analysis
Adult
Blood plasma
Blood Urea Nitrogen - analysis
Cardiomyopathy, Hypertrophic - drug therapy
Cardiomyopathy, Hypertrophic - pathology
Coronary artery disease
Coronary Disease - drug therapy
Coronary Disease - pathology
Digoxin - analysis
Digoxin - therapeutic use
Female
Fibrosis
Heart
Heart atria
Heart Atria - analysis
Heart Transplantation
Heart ventricles
Heart Ventricles - analysis
Histology
Humans
Magnesium - analysis
Male
Microsomes - analysis
Middle Aged
Myocardium - analysis
Myocardium - pathology
Papers and Originals
Pharmacology
Potassium - analysis
Radioimmunoassay
Receptors
Sodium - analysis
Transplantation, Homologous
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Summary:Using the recipient's human heart removed at cardiac transplantation, the distribution of digoxin at both the cellular and subcellular level has been studied. In the presence of diffuse histological myocardial abnormalities tissue digoxin is decreased, but the subcellular distribution, presumably reflecting binding to a possible receptor site, is uniform. When the histological abnormality is focal then digoxin distribution is uniform. These results suggest that in the presence of myocardial ischaemia plasma digoxin concentrations may not reflect total myocardial levels accurately.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.4.5947.733