Self-induced Glomerulonephritis

A patient is described who developed renal failure due to a severe proliferative glomerulonephritis with hypocomplementaemia and cryoglobulinaemia while repeatedly injecting herself with diphtheria, pertussis, and tetanus vaccine (D.P.T. vaccine). After stopping the antigen administration there was...

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Bibliographic Details
Published in:BMJ 1974-08, Vol.3 (5927), p.387-390
Main Authors: Boulton-Jones, J. M., Sissons, J. G. P., Naish, P. F., Evans, D. J., Peters, D. K.
Format: Article
Language:English
Subjects:
Adult
Antibodies
Antibodies - analysis
Antigens
Antigens - administration & dosage
Biopsies
Biopsy
Creatinine - blood
Cryoglobulins
Diphtheria
Diphtheria Toxoid - administration & dosage
Female
Glomerulonephritis
Glomerulonephritis - etiology
Glomerulonephritis - immunology
Humans
Immunization - adverse effects
Injections, Intra-Articular
Kidney - pathology
Kidney Failure, Chronic - etiology
Kidney Failure, Chronic - immunology
Lesions
Papers and Originals
Pertussis Vaccine - administration & dosage
Substance-Related Disorders
Tetanus
Tetanus Toxoid - administration & dosage
Vaccination
Whooping cough
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Description
Summary:A patient is described who developed renal failure due to a severe proliferative glomerulonephritis with hypocomplementaemia and cryoglobulinaemia while repeatedly injecting herself with diphtheria, pertussis, and tetanus vaccine (D.P.T. vaccine). After stopping the antigen administration there was recovery of renal function, complement values returned to normal, and cryoglobulin could no longer be recovered from the sera. The pathogenesis of the glomerulonephritis is discussed.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.3.5927.387