Activation of insulin‐like growth factor I receptor‐mediated pathway by ginsenoside Rg1

Ginsenoside Rg1, an active ingredient in ginseng, was previously shown to be a novel class of potent phytoestrogen. The present study aims at investigating the molecular mechanisms involved in mediating its actions in human breast cancer (MCF‐7) cells. Rg1 (1 pM) stimulates cell proliferation (P

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Bibliographic Details
Published in:British journal of pharmacology 2006-03, Vol.147 (5), p.542-551
Main Authors: Chen, Wen‐Fang, Lau, Wai‐Sum, Cheung, Pik‐Yuen, Guo, De‐An, Wong, Man‐Sau
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Line
Cell Proliferation - drug effects
estrogen
Estrogen Receptor alpha - physiology
Ginsenoside Rg1
Ginsenosides - pharmacology
Gynecology. Andrology. Obstetrics
human breast cancer
Humans
Insulin-Like Growth Factor I - pharmacology
insulin‐like growth factor I receptor
Mammary gland diseases
Medical sciences
Pharmacology. Drug treatments
phytoestrogen
Promoter Regions, Genetic
Receptor, IGF Type 1 - drug effects
Receptor, IGF Type 1 - genetics
Receptor, IGF Type 1 - physiology
RNA, Messenger - analysis
Signal Transduction - drug effects
Trefoil Factor-1
Tumor Suppressor Proteins - genetics
Tumors
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Description
Summary:Ginsenoside Rg1, an active ingredient in ginseng, was previously shown to be a novel class of potent phytoestrogen. The present study aims at investigating the molecular mechanisms involved in mediating its actions in human breast cancer (MCF‐7) cells. Rg1 (1 pM) stimulates cell proliferation (P
ISSN:0007-1188
1476-5381
DOI:10.1038/sj.bjp.0706640