Uncovering hidden in vivo resonances using editing based on localized TOCSY

A novel single‐shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low‐concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J‐coupled spins from selected coupling p...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2005-04, Vol.53 (4), p.783-789
Main Authors: Marjanska, Malgorzata, Henry, Pierre-Gilles, Bolan, Patrick J., Vaughan, Brooks, Seaquist, Elizabeth R., Gruetter, Rolf, Uğurbil, Kâmil, Garwood, Michael
Format: Article
Language:English
Subjects:
adiabatic pulses
Animals
Brain - metabolism
Brain Chemistry
editing
glucose
Glucose - metabolism
Humans
lactate
Lactic Acid - metabolism
Magnetic Resonance Spectroscopy - methods
Male
Phantoms, Imaging
Rats
Rats, Sprague-Dawley
Signal Processing, Computer-Assisted
spectroscopy
TOCSY
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Summary:A novel single‐shot spectral editing technique for in vivo proton NMR is proposed to recover resonances of low‐concentration metabolites obscured by very strong resonances. With this new method, editing is performed by transferring transverse magnetization to J‐coupled spins from selected coupling partners using a homonuclear Hartmann–Hahn polarization transfer with adiabatic pulses. The current implementation uses 1D‐TOCSY with single‐voxel localization based on LASER to recover the H1 proton of β‐glucose at 4.63 ppm from under water and the lactate methyl resonances from beneath a strong lipid signal. The method can be extended to further spin systems where conventional editing methods are difficult to perform. Magn Reson Med 53:783–789, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.20425