GH peak response to GHRH-arginine: relationship to insulin resistance and other cardiovascular risk factors in a population of adults aged 50-90

Summary Objective  To assess the GH response to GHRH‐arginine in apparently healthy adults in relation to cardiovascular risk factors. Design  Cross‐sectional. Patients  Eighty‐six male and female volunteers aged 50–90. Measurements  GH peak response to GHRH‐arginine and cardiovascular risk factors,...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2006-08, Vol.65 (2), p.169-177
Main Authors: Carmichael, John D., Danoff, Ann, Milani, Daniela, Roubenoff, Ronenn, Lesser, Martin L., Livote, Elayne, Reitz, Richard E., Ferris, Steven, Kleinberg, David L.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Aged
Aged, 80 and over
Arginine
Biological and medical sciences
Blood Glucose - analysis
Body Composition
Body Mass Index
Cardiovascular Diseases - etiology
Cross-Sectional Studies
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Growth Hormone - blood
Growth Hormone-Releasing Hormone
Homeostasis
Humans
Insulin - blood
Insulin Resistance
Insulin-Like Growth Factor I - analysis
Male
Medical sciences
Middle Aged
Original
Regression Analysis
Risk Factors
Vertebrates: endocrinology
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Summary:Summary Objective  To assess the GH response to GHRH‐arginine in apparently healthy adults in relation to cardiovascular risk factors. Design  Cross‐sectional. Patients  Eighty‐six male and female volunteers aged 50–90. Measurements  GH peak response to GHRH‐arginine and cardiovascular risk factors, including obesity, insulin resistance, low levels of high density lipoprotein (HDL) cholesterol, elevated triglycerides, and hypertension. The primary outcome measurement was GH response to GHRH‐arginine. The relationship between GH peak responses and cardiovascular risk factors was determined after data collection. Results  GH peaks were highly variable, ranging from 2·3 to 185 µg/l (14% with GH peaks
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2006.02569.x