Prostaglandin E1 in suspected ductus dependent cardiac malformation

Fifty two sick neonates with major duct dependent cardiac defects were given short term intravenous infusions of prostaglandin E1 (alprostadil) in doses varying between 0.005 and 0.1 micrograms/kg/minute. The object of the study was to try to achieve an effective but safe regiment that could be inst...

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Bibliographic Details
Published in:Archives of disease in childhood 1984-11, Vol.59 (11), p.1020-1026
Main Author: Hallidie-Smith, K A
Format: Article
Language:English
Subjects:
Alprostadil
Apnea - chemically induced
Biological and medical sciences
Blood Circulation - drug effects
Cardiovascular system
Dose-Response Relationship, Drug
Drug Administration Schedule
Ductus Arteriosus - drug effects
Heart Defects, Congenital - blood
Heart Defects, Congenital - drug therapy
Heart Defects, Congenital - physiopathology
Humans
Infant, Newborn
Medical sciences
Miscellaneous
Oxygen - blood
Pharmacology. Drug treatments
Prostaglandins E - administration & dosage
Prostaglandins E - adverse effects
Prostaglandins E - therapeutic use
Pulmonary Circulation - drug effects
Seizures - chemically induced
Vasodilator Agents - therapeutic use
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Summary:Fifty two sick neonates with major duct dependent cardiac defects were given short term intravenous infusions of prostaglandin E1 (alprostadil) in doses varying between 0.005 and 0.1 micrograms/kg/minute. The object of the study was to try to achieve an effective but safe regiment that could be instituted as soon as such a diagnosis was suspected. Effective clinical improvement was achieved at each dosage but the incidence of side effects seemed to be dose related, and no serious side effects were noted at a dosage of 0.005 to 0.01 micrograms/kg/minute. It is recommended that a low dosage regimen be started before transfer to a paediatric cardiac centre.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.59.11.1020