Loading…

Synaptic plasticity: one STEP at a time

Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these su...

Full description

Saved in:

Bibliographic Details
Published in:	Trends in neurosciences (Regular ed.) 2006-08, Vol.29 (8), p.452-458
Main Authors:	Braithwaite, Steven P., Paul, Surojit, Nairn, Angus C., Lombroso, Paul J.
Format:	Article
Language:	English
Subjects:	Alzheimer's disease Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Medical sciences Models, Biological Neurology Neuronal Plasticity - physiology Neurons Phosphates Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Signal Transduction - physiology Synapses - metabolism Vertebrates: nervous system and sense organs
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by	cdi_FETCH-LOGICAL-c541t-d672f49d0b98be625f8c5ab69568dab987924f882464127b8b91057bc16672623
cites	cdi_FETCH-LOGICAL-c541t-d672f49d0b98be625f8c5ab69568dab987924f882464127b8b91057bc16672623
container_end_page	458
container_issue	8
container_start_page	452
container_title	Trends in neurosciences (Regular ed.)
container_volume	29
creator	Braithwaite, Steven P. Paul, Surojit Nairn, Angus C. Lombroso, Paul J.
description	Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these substrates, STEP acts on several parallel pathways that impact upon the progression of synaptic plasticity. Here, we review recent advances that demonstrate the importance of STEP in normal cognitive function, and its possible involvement in cognitive disorders such as Alzheimer's disease.
doi_str_mv	10.1016/j.tins.2006.06.007
format	article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1630769</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0166223606001214</els_id><sourcerecordid>1152558991</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-d672f49d0b98be625f8c5ab69568dab987924f882464127b8b91057bc16672623</originalsourceid><addsrcrecordid>eNqFkdFrFDEQxoMo9lr7D_ggi2B92nOSy04SkUIprRYKFVrBt5DNZjXHXvZMcoX7781yR1t9UBgYSH7z8c18hLymMKdA8cNynn1IcwaA86lAPCMzKoWsKcjvz8msQFgztsADcpjSEoBySflLckBRAjYUZuT97TaYdfa2Wg8mle7z9mM1Blfd3l18rUyuTJX9yr0iL3ozJHe870fk2-XF3fmX-vrm89X52XVtG05z3aFgPVcdtEq2DlnTS9uYFlWDsjPlUSjGeykZR06ZaGWrKDSitcWpYMgWR-R0p7vetCvXWRdyNINeR78ycatH4_WfP8H_1D_Ge01xAQJVETjZC8Tx18alrFc-WTcMJrhxkzRKAQsu5H9BqphijYICvv0LXI6bGMoVNCvXbsouE8R2kI1jStH1D5Yp6CktvdRTWnpKS08Fogy9ebrs48g-ngK82wMmWTP00QTr0yMngSNjWLhPO86VaO69izpZ74J1nY_OZt2N_l8-fgPWKLBH</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>218752460</pqid></control><display><type>article</type><title>Synaptic plasticity: one STEP at a time</title><source>ScienceDirect Journals</source><creator>Braithwaite, Steven P. ; Paul, Surojit ; Nairn, Angus C. ; Lombroso, Paul J.</creator><creatorcontrib>Braithwaite, Steven P. ; Paul, Surojit ; Nairn, Angus C. ; Lombroso, Paul J.</creatorcontrib><description>Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these substrates, STEP acts on several parallel pathways that impact upon the progression of synaptic plasticity. Here, we review recent advances that demonstrate the importance of STEP in normal cognitive function, and its possible involvement in cognitive disorders such as Alzheimer's disease.</description><identifier>ISSN: 0166-2236</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/j.tins.2006.06.007</identifier><identifier>PMID: 16806510</identifier><identifier>CODEN: TNSCDR</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Alzheimer's disease ; Animals ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Fundamental and applied biological sciences. Psychology ; General aspects. Models. Methods ; Humans ; Medical sciences ; Models, Biological ; Neurology ; Neuronal Plasticity - physiology ; Neurons ; Phosphates ; Protein Tyrosine Phosphatases - genetics ; Protein Tyrosine Phosphatases - metabolism ; Signal Transduction - physiology ; Synapses - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Trends in neurosciences (Regular ed.), 2006-08, Vol.29 (8), p.452-458</ispartof><rights>2006 Elsevier Ltd</rights><rights>2006 INIST-CNRS</rights><rights>Copyright Elsevier Sequoia S.A. Aug 2006</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-d672f49d0b98be625f8c5ab69568dab987924f882464127b8b91057bc16672623</citedby><cites>FETCH-LOGICAL-c541t-d672f49d0b98be625f8c5ab69568dab987924f882464127b8b91057bc16672623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18046226$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16806510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Braithwaite, Steven P.</creatorcontrib><creatorcontrib>Paul, Surojit</creatorcontrib><creatorcontrib>Nairn, Angus C.</creatorcontrib><creatorcontrib>Lombroso, Paul J.</creatorcontrib><title>Synaptic plasticity: one STEP at a time</title><title>Trends in neurosciences (Regular ed.)</title><addtitle>Trends Neurosci</addtitle><description>Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these substrates, STEP acts on several parallel pathways that impact upon the progression of synaptic plasticity. Here, we review recent advances that demonstrate the importance of STEP in normal cognitive function, and its possible involvement in cognitive disorders such as Alzheimer's disease.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General aspects. Models. Methods</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Neurology</subject><subject>Neuronal Plasticity - physiology</subject><subject>Neurons</subject><subject>Phosphates</subject><subject>Protein Tyrosine Phosphatases - genetics</subject><subject>Protein Tyrosine Phosphatases - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Synapses - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0166-2236</issn><issn>1878-108X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2006</creationdate><recordtype>article</recordtype><recordid>eNqFkdFrFDEQxoMo9lr7D_ggi2B92nOSy04SkUIprRYKFVrBt5DNZjXHXvZMcoX7781yR1t9UBgYSH7z8c18hLymMKdA8cNynn1IcwaA86lAPCMzKoWsKcjvz8msQFgztsADcpjSEoBySflLckBRAjYUZuT97TaYdfa2Wg8mle7z9mM1Blfd3l18rUyuTJX9yr0iL3ozJHe870fk2-XF3fmX-vrm89X52XVtG05z3aFgPVcdtEq2DlnTS9uYFlWDsjPlUSjGeykZR06ZaGWrKDSitcWpYMgWR-R0p7vetCvXWRdyNINeR78ycatH4_WfP8H_1D_Ge01xAQJVETjZC8Tx18alrFc-WTcMJrhxkzRKAQsu5H9BqphijYICvv0LXI6bGMoVNCvXbsouE8R2kI1jStH1D5Yp6CktvdRTWnpKS08Fogy9ebrs48g-ngK82wMmWTP00QTr0yMngSNjWLhPO86VaO69izpZ74J1nY_OZt2N_l8-fgPWKLBH</recordid><startdate>20060801</startdate><enddate>20060801</enddate><creator>Braithwaite, Steven P.</creator><creator>Paul, Surojit</creator><creator>Nairn, Angus C.</creator><creator>Lombroso, Paul J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><general>Elsevier Sequoia S.A</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20060801</creationdate><title>Synaptic plasticity: one STEP at a time</title><author>Braithwaite, Steven P. ; Paul, Surojit ; Nairn, Angus C. ; Lombroso, Paul J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-d672f49d0b98be625f8c5ab69568dab987924f882464127b8b91057bc16672623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2006</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>General aspects. Models. Methods</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Neurology</topic><topic>Neuronal Plasticity - physiology</topic><topic>Neurons</topic><topic>Phosphates</topic><topic>Protein Tyrosine Phosphatases - genetics</topic><topic>Protein Tyrosine Phosphatases - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Synapses - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Braithwaite, Steven P.</creatorcontrib><creatorcontrib>Paul, Surojit</creatorcontrib><creatorcontrib>Nairn, Angus C.</creatorcontrib><creatorcontrib>Lombroso, Paul J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Trends in neurosciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Braithwaite, Steven P.</au><au>Paul, Surojit</au><au>Nairn, Angus C.</au><au>Lombroso, Paul J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synaptic plasticity: one STEP at a time</atitle><jtitle>Trends in neurosciences (Regular ed.)</jtitle><addtitle>Trends Neurosci</addtitle><date>2006-08-01</date><risdate>2006</risdate><volume>29</volume><issue>8</issue><spage>452</spage><epage>458</epage><pages>452-458</pages><issn>0166-2236</issn><eissn>1878-108X</eissn><coden>TNSCDR</coden><abstract>Striatal enriched tyrosine phosphatase (STEP) has recently been identified as a crucial player in the regulation of synaptic function. It is restricted to neurons within the CNS and acts by downregulating the activity of MAP kinases, the tyrosine kinase Fyn and NMDA receptors. By modulating these substrates, STEP acts on several parallel pathways that impact upon the progression of synaptic plasticity. Here, we review recent advances that demonstrate the importance of STEP in normal cognitive function, and its possible involvement in cognitive disorders such as Alzheimer's disease.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>16806510</pmid><doi>10.1016/j.tins.2006.06.007</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext	fulltext
identifier	ISSN: 0166-2236
ispartof	Trends in neurosciences (Regular ed.), 2006-08, Vol.29 (8), p.452-458
issn	0166-2236 1878-108X
language	eng
recordid	cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1630769
source	ScienceDirect Journals
subjects	Alzheimer's disease Animals Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology General aspects. Models. Methods Humans Medical sciences Models, Biological Neurology Neuronal Plasticity - physiology Neurons Phosphates Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism Signal Transduction - physiology Synapses - metabolism Vertebrates: nervous system and sense organs
title	Synaptic plasticity: one STEP at a time
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A03%3A03IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synaptic%20plasticity:%20one%20STEP%20at%20a%20time&rft.jtitle=Trends%20in%20neurosciences%20(Regular%20ed.)&rft.au=Braithwaite,%20Steven%20P.&rft.date=2006-08-01&rft.volume=29&rft.issue=8&rft.spage=452&rft.epage=458&rft.pages=452-458&rft.issn=0166-2236&rft.eissn=1878-108X&rft.coden=TNSCDR&rft_id=info:doi/10.1016/j.tins.2006.06.007&rft_dat=%3Cproquest_pubme%3E1152558991%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c541t-d672f49d0b98be625f8c5ab69568dab987924f882464127b8b91057bc16672623%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=218752460&rft_id=info:pmid/16806510&rfr_iscdi=true