Accidental percutaneous hexachlorophane intoxication in children

Eighteen children with normal skin were accidentally intoxicated by a talc powder containing 6% hexachlorophane. Four died and two remained paraplegic. The clinical picture was intracranial hypertension, eight patients developing signs of spinal cord damage. The condition seemed to result from massi...

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Bibliographic Details
Published in:BMJ 1977-09, Vol.2 (6088), p.663-665
Main Authors: Goutières, F, Aicardi, J
Format: Article
Language:English
Subjects:
Child health services
Child, Preschool
Children
Edema
Female
Hexachlorophene - poisoning
Hospital admissions
Humans
Infant
Infants
Intoxication
Intracranial Pressure
Lesions
Male
Pediatrics
Skin Absorption
Spinal cord
Spinal Cord - pathology
Talc - poisoning
White matter
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Summary:Eighteen children with normal skin were accidentally intoxicated by a talc powder containing 6% hexachlorophane. Four died and two remained paraplegic. The clinical picture was intracranial hypertension, eight patients developing signs of spinal cord damage. The condition seemed to result from massive intramyelinic oedema. In the spinal cord vascular disturbances may occur as mechanical complications of oedema, giving rise to permanent sequelae.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.6088.663