Diurnal plasma free fatty acid profiles in normal and diabetic pregnancies

Diurnal plasma free fatty acid (FFA) and glucose concentrations were measured in 23 normal women, 13 chemical diabetics, and 11 insulin-dependent diabetics in late pregnancy. The mean diurnal FFA value was lowest in the insulin-requiring diabetics and highest in the chemical diabetics. Although no a...

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Bibliographic Details
Published in:BMJ 1977-09, Vol.2 (6088), p.670-673
Main Authors: Gillmer, M D, Beard, R W, Oakley, N W, Brooke, F M, Elphick, M C, Hull, D
Format: Article
Language:English
Subjects:
Adult
Birth Weight
Blood Glucose - analysis
Blood plasma
Circadian Rhythm
Condensed Report
Diabetes
Diabetes complications
Fasting
Fatty Acids, Nonesterified - blood
Female
Humans
Insulin
Insulin - pharmacology
Nonesterified fatty acids
Pregnancy
Pregnancy in diabetics
Pregnancy in Diabetics - blood
Type 1 diabetes mellitus
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Summary:Diurnal plasma free fatty acid (FFA) and glucose concentrations were measured in 23 normal women, 13 chemical diabetics, and 11 insulin-dependent diabetics in late pregnancy. The mean diurnal FFA value was lowest in the insulin-requiring diabetics and highest in the chemical diabetics. Although no association was found between percentile birthweight and maternal mean fasting or diurnal FFA, there was a positive correlation between percentile birthweight and both mean maternal fasting plasma glucose and mean diurnal glucose in normal and chemical diabetic women. These observations support the view that glucose is the major substrate used by the fetus, but birthweight may be influenced more by the total substrate crossing the placenta than by maternal levels of either glucose or FFA alone.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.6088.670