Extra-articular features in early rheumatoid disease

One hundred and two patients who presented with rheumatoid disease within the first year of onset were studied prospectively every four months for a mean 4.5 years to assess the incidence of extra-articular features. The features that seemed to be common in the early stages included hand-muscle wast...

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Bibliographic Details
Published in:BMJ 1976-05, Vol.1 (6020), p.1241-1243
Main Authors: Fleming, A, Dodman, S, Crown, J M, Corbett, M
Format: Article
Language:English
Subjects:
Adult
Aged
Body Weight
Disease manifestations
Epidemiology
Female
Health outcomes
Hepatomegaly - complications
Humans
Joint diseases
Lymphadenitis - complications
Lymphatic diseases
Male
Middle Aged
Muscular Diseases - complications
Nerve Compression Syndromes - complications
Nervous system diseases
Prognosis
Prospective Studies
Reiter syndrome
Rheumatic Diseases - complications
Rheumatoid Nodule - complications
Rheumatoid nodules
Rheumatology
Underweight
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Summary:One hundred and two patients who presented with rheumatoid disease within the first year of onset were studied prospectively every four months for a mean 4.5 years to assess the incidence of extra-articular features. The features that seemed to be common in the early stages included hand-muscle wasting, carpal tunnel syndrome, lymphadenopathy, non-specific ankle swelling, and rheumatoid nodules, and to a lesser extent hepatomegaly, being underweight, conjunctivitis, skin transparency, and a palpable thyroid gland. Those features which seldom occurred early included scleromalacia, temporal artery inolvement, salivary gland enlargement, distal-motor neuropathy, splenomegaly, digital vasculitis, and pulmonary and cardiac complications. Being underweight indicated a significantly more severe outcome.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.1.6020.1241