Absorption of Amino Acids and Peptides in a Child with a Variant of Hartnup Disease and Coexistent Coeliac Disease

A child with a variant of Hartnup disease and co-existent coeliac disease is described. Oral tolerance tests with L-histidine, L-tyrosine, and glycyl-L-tyrosine, and in vitro uptake studies on a small intestinal biopsy with L-histidine and glycyl-L-histidine, showed impaired absorption of the free a...

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Bibliographic Details
Published in:Archives of disease in childhood 1972-10, Vol.47 (255), p.798-803
Main Authors: Tarlow, M. J., Seakins, J. W. T., Lloyd, June K., Matthews, D. M., Cheng, B., Thomas, A. J.
Format: Article
Language:English
Subjects:
Absorption
Amino Acid Metabolism, Inborn Errors
Amino acids
Amino Acids - metabolism
Amino Acids - urine
Biopsy
Celiac Disease - complications
Celiac Disease - metabolism
Dipeptides - metabolism
Glycine - metabolism
Hartnup Disease - complications
Hartnup Disease - metabolism
Histidine - blood
Histidine - metabolism
Humans
Infant
Intestinal Absorption
Intestine, Small - metabolism
Jejunum - metabolism
Male
Peptides
Peptides - metabolism
Review
Tyrosine - metabolism
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Summary:A child with a variant of Hartnup disease and co-existent coeliac disease is described. Oral tolerance tests with L-histidine, L-tyrosine, and glycyl-L-tyrosine, and in vitro uptake studies on a small intestinal biopsy with L-histidine and glycyl-L-histidine, showed impaired absorption of the free amino acids, and showed that absorption of tyrosine and mucosal uptake of histidine was better from the dipeptides than from the free amino acids. This supports the hypothesis that the intestinal mucosa can take up small peptides intact, and that the peptide uptake mechanism is not involved in the intestinal defect of Hartnup disease.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.47.255.798