Night and Day Growth Hormone Levels During Treatment with Corticosteroids and Corticotrophin

Night and day rhythms of HGH secretion were measured in 5 children before any treatment, 10 days after prednisone administration, and 3 days after ACTH treatment. Corticosteroids and corticotrophin were found to have a pronounced effect on the spontaneous level of HGH with the almost complete disapp...

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Bibliographic Details
Published in:Archives of disease in childhood 1972-08, Vol.47 (254), p.605-608
Main Authors: Pantelakis, S. N., Sinaniotis, C. A., Sbirakis, S., Ikkos, D., Doxiadis, S. A.
Format: Article
Language:English
Subjects:
Adolescent
Adrenocorticotropic Hormone - therapeutic use
Child
Circadian Rhythm
Corticoids
Female
Growth Hormone - blood
Humans
Iodine Isotopes
Male
Prednisone - therapeutic use
Radioimmunoassay
Review
Rheumatic Fever - drug therapy
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Summary:Night and day rhythms of HGH secretion were measured in 5 children before any treatment, 10 days after prednisone administration, and 3 days after ACTH treatment. Corticosteroids and corticotrophin were found to have a pronounced effect on the spontaneous level of HGH with the almost complete disappearance of the normally observed peaks during the 24 hours in the pretreatment study. It is postulated that this disappearance of the spontaneous peaks might explain in part the growth retardation noticed in children on long-term treatment with corticosteroids or corticotrophin.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.47.254.605