Cyclic chemotherapy in acute lymphoblastic leukaemia of childhood: 5-year survivals

Of 31 children with acute lymphoblastic leukaemia treated with a cyclical scheme of chemotherapy, 19% survived for over 5 years, 16% remained in continuing haematological remission for 5 years, and 13% remained leukaemia free for 5 years. These findings are relevant to potential cure, unlike the med...

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Bibliographic Details
Published in:Archives of disease in childhood 1973-06, Vol.48 (6), p.436-440
Main Authors: Vowels, M R, Willoughby, M L
Format: Article
Language:English
Subjects:
Acute Disease
Bone Marrow Cells
Child
Cyclophosphamide - administration & dosage
Cyclophosphamide - therapeutic use
Humans
Leukemia, Lymphoid - drug therapy
Leukemia, Lymphoid - mortality
Leukemia, Lymphoid - pathology
Mercaptopurine - administration & dosage
Mercaptopurine - therapeutic use
Methotrexate - administration & dosage
Original
Prednisolone - administration & dosage
Prednisolone - therapeutic use
Remission, Spontaneous
Vincristine - administration & dosage
Vincristine - therapeutic use
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Summary:Of 31 children with acute lymphoblastic leukaemia treated with a cyclical scheme of chemotherapy, 19% survived for over 5 years, 16% remained in continuing haematological remission for 5 years, and 13% remained leukaemia free for 5 years. These findings are relevant to potential cure, unlike the median remission duration, which is a measure of palliation. A relation between the percentage of PAS-positive blast cells at diagnosis and duration of control of the disease still pertains for the long-term results in this series of patients.
ISSN:0003-9888
1468-2044
DOI:10.1136/adc.48.6.436