Inflammatory breast cancer: vasculogenic mimicry and its hemodynamics of an inflammatory breast cancer xenograft model

We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC. The original tumor and WIBC-9 revealed invasive ductal carcinoma with a hypervascular structure of solid nests and marked lymphatic permeation in the overlying dermis. In the...

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Bibliographic Details
Published in:Breast cancer research : BCR 2003-01, Vol.5 (3), p.136-139, Article 136
Main Authors: Shirakawa, Kazuo, Kobayashi, Hisataka, Sobajima, Jun, Hashimoto, Daijo, Shimizu, Atsushi, Wakasugi, Hiro
Format: Article
Language:English
Subjects:
Animals
Blood Vessels - pathology
Breast cancer
Breast Neoplasms - blood supply
Breast Neoplasms - genetics
Breast Neoplasms - pathology
Breast Neoplasms - ultrastructure
Chromosome Aberrations
Contrast media
Cytogenetic Analysis
Disease Models, Animal
Endothelium
Endothelium, Vascular - pathology
Endothelium, Vascular - ultrastructure
Hemodynamics - genetics
Humans
Inflammation - genetics
Magnetic Resonance Angiography
Mice
Mice, Inbred BALB C
Mice, Nude
Microscopy, Electron
Neoplasm Transplantation
Neovascularization, Pathologic
Paraffin Embedding
Review
Time Factors
Transplantation, Heterologous - methods
Tumor Cells, Cultured
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Summary:We recently established a new human inflammatory breast cancer (IBC) xenograft (WIBC-9) originating from a patient with IBC. The original tumor and WIBC-9 revealed invasive ductal carcinoma with a hypervascular structure of solid nests and marked lymphatic permeation in the overlying dermis. In the central part of the solid nests, vasculogenic mimicry, which showed an absence of endothelial cells, was observed. Comparison of WIBC-9 with an established non-IBC xenograft (MC-5), using time-course dynamic micro-magnetic resonance angiography analysis (with a newly developed intravascular macromolecular contrast agent for magnetic resonance imaging) demonstrated that the WIBC-9 tumor had blood flow and a vascular mimicry-angiogenesis junction.
ISSN:1465-542X
1465-5411
1465-542X
DOI:10.1186/bcr585