Folic acid, homocysteine, and cardiovascular disease: judging causality in the face of inconclusive trial evidence

Increasing intake of folic acid would be a relatively cheap and simple way of reducing heart disease, if it works. Can we draw a definitive conclusion from the current evidence?

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Bibliographic Details
Published in:BMJ 2006-11, Vol.333 (7578), p.1114-1117
Main Authors: Wald, David S, Wald, Nicholas J, Morris, Joan K, Law, Malcolm
Format: Article
Language:English
Subjects:
Analysis and Comment
Biochemistry
Biological and medical sciences
Cardiovascular disease
Cardiovascular diseases
Cardiovascular Diseases - blood
Cardiovascular Diseases - prevention & control
Causality
Cohort Studies
Evidence-Based Medicine
Folic Acid - administration & dosage
General aspects
Health risk assessment
Heart attacks
Homocysteine - blood
Homocystinuria - etiology
Humans
Medical research
Medical sciences
Mutation
Polymorphism
Polymorphism, Genetic
Prevention
Randomized Controlled Trials as Topic
Risk factors
Stroke
Studies
Vitamin B
Citations: Items that cite this one
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Description
Summary:Increasing intake of folic acid would be a relatively cheap and simple way of reducing heart disease, if it works. Can we draw a definitive conclusion from the current evidence?
ISSN:0959-8138
0959-8146
0959-535X
1756-1833
1468-5833
1756-1833
DOI:10.1136/bmj.39000.486701.68