3H‐Noradrenaline‐accumulating ability of cholinergic nerve terminals in cat sympathetic ganglia

Summary 1 After incubation of pieces of cat posterior mesenteric ganglion in [3H]‐noradrenaline solution, the localization of the isotope was assessed by electronautoradiography. 2 Significantly higher concentrations of [3H]‐noradrenaline were found over acetylcholinesterase‐positive axons terminal...

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Bibliographic Details
Published in:British journal of pharmacology 1971-11, Vol.43 (3), p.555-559
Main Authors: GRAHAM, J. D. P., IVENS, CAROLINE, JOÓ, F., LEVER, J. D., MOTTRAM, D. R., SPRIGGS, T. L. B.
Format: Article
Language:English
Subjects:
Autopharmacology
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Summary:Summary 1 After incubation of pieces of cat posterior mesenteric ganglion in [3H]‐noradrenaline solution, the localization of the isotope was assessed by electronautoradiography. 2 Significantly higher concentrations of [3H]‐noradrenaline were found over acetylcholinesterase‐positive axons terminal on ganglion cells than in adjacent background areas. 3 [3H]‐Noradrenaline was not accumulated by ganglion cells under these circumstances. 4 The significance of these findings in relation to previous physiological and pharmacological investigation is discussed.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1971.tb07185.x