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In vivo production of steroids with central depressant actions by the ovary of the rat
Summary 1 In addition to progesterone and 20‐dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue and ovarian venous blood of mature, non‐pregnant rats: pregnenolone, 3βOH‐5α‐pregnan‐20‐one, 3αOH‐5α‐pregnan‐20‐one, 20αOH‐5α‐pregnan‐3‐one and 5α‐pregnane‐3α, 20α‐...
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| Published in: | British journal of pharmacology 1971-11, Vol.43 (3), p.560-569 |
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| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c4776-3dc79609fc215e8369492188c7f1d0ad3464c1ecd5d58106b0a9b991944d02033 |
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| cites | cdi_FETCH-LOGICAL-c4776-3dc79609fc215e8369492188c7f1d0ad3464c1ecd5d58106b0a9b991944d02033 |
| container_end_page | 569 |
| container_issue | 3 |
| container_start_page | 560 |
| container_title | British journal of pharmacology |
| container_volume | 43 |
| creator | HOLZBAUER, MARGARETHE |
| description | Summary
1
In addition to progesterone and 20‐dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue and ovarian venous blood of mature, non‐pregnant rats: pregnenolone, 3βOH‐5α‐pregnan‐20‐one, 3αOH‐5α‐pregnan‐20‐one, 20αOH‐5α‐pregnan‐3‐one and 5α‐pregnane‐3α, 20α‐diol.
2
Their concentration in the ovarian tissue and their secretion rates into the ovarian venous blood was of the same order of magnitude as that of progesterone.
3
In the evening of the day of pro‐oestrus significant increases in the ovarian contents of the following steroids were observed: progesterone,+ 140%; 3αOH‐5α‐pregnan‐20‐one, +320%; 20αOH‐5α‐pregnan‐3‐one, +195%; sum of pregnenolone and 3βOH‐5α‐pregnan‐20‐one, +275%.
4
At the same time the ovarian progesterone secretion rate was increased by 365%, that of 3αOH‐5α‐pregnan‐20‐one by 190%.
5
A possible physiological role of the ovarian allopregnane derivatives as central depressant agents is discussed. |
| doi_str_mv | 10.1111/j.1476-5381.1971.tb07186.x |
| format | article |
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1
In addition to progesterone and 20‐dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue and ovarian venous blood of mature, non‐pregnant rats: pregnenolone, 3βOH‐5α‐pregnan‐20‐one, 3αOH‐5α‐pregnan‐20‐one, 20αOH‐5α‐pregnan‐3‐one and 5α‐pregnane‐3α, 20α‐diol.
2
Their concentration in the ovarian tissue and their secretion rates into the ovarian venous blood was of the same order of magnitude as that of progesterone.
3
In the evening of the day of pro‐oestrus significant increases in the ovarian contents of the following steroids were observed: progesterone,+ 140%; 3αOH‐5α‐pregnan‐20‐one, +320%; 20αOH‐5α‐pregnan‐3‐one, +195%; sum of pregnenolone and 3βOH‐5α‐pregnan‐20‐one, +275%.
4
At the same time the ovarian progesterone secretion rate was increased by 365%, that of 3αOH‐5α‐pregnan‐20‐one by 190%.
5
A possible physiological role of the ovarian allopregnane derivatives as central depressant agents is discussed.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1971.tb07186.x</identifier><identifier>PMID: 5168235</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; Autopharmacology ; Brain - drug effects ; Chromatography, Gas ; Chromatography, Paper ; Estrus ; Female ; Hydroxyprogesterones - biosynthesis ; Hypnotics and Sedatives - pharmacology ; Ovary - metabolism ; Pregnancy ; Pregnanes - biosynthesis ; Pregnanes - pharmacology ; Pregnenolone - biosynthesis ; Progesterone - biosynthesis ; Rats ; Secretory Rate ; Sterols - biosynthesis</subject><ispartof>British journal of pharmacology, 1971-11, Vol.43 (3), p.560-569</ispartof><rights>1971 British Pharmacological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4776-3dc79609fc215e8369492188c7f1d0ad3464c1ecd5d58106b0a9b991944d02033</citedby><cites>FETCH-LOGICAL-c4776-3dc79609fc215e8369492188c7f1d0ad3464c1ecd5d58106b0a9b991944d02033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665797/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1665797/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5168235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HOLZBAUER, MARGARETHE</creatorcontrib><title>In vivo production of steroids with central depressant actions by the ovary of the rat</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>Summary
1
In addition to progesterone and 20‐dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue and ovarian venous blood of mature, non‐pregnant rats: pregnenolone, 3βOH‐5α‐pregnan‐20‐one, 3αOH‐5α‐pregnan‐20‐one, 20αOH‐5α‐pregnan‐3‐one and 5α‐pregnane‐3α, 20α‐diol.
2
Their concentration in the ovarian tissue and their secretion rates into the ovarian venous blood was of the same order of magnitude as that of progesterone.
3
In the evening of the day of pro‐oestrus significant increases in the ovarian contents of the following steroids were observed: progesterone,+ 140%; 3αOH‐5α‐pregnan‐20‐one, +320%; 20αOH‐5α‐pregnan‐3‐one, +195%; sum of pregnenolone and 3βOH‐5α‐pregnan‐20‐one, +275%.
4
At the same time the ovarian progesterone secretion rate was increased by 365%, that of 3αOH‐5α‐pregnan‐20‐one by 190%.
5
A possible physiological role of the ovarian allopregnane derivatives as central depressant agents is discussed.</description><subject>Animals</subject><subject>Autopharmacology</subject><subject>Brain - drug effects</subject><subject>Chromatography, Gas</subject><subject>Chromatography, Paper</subject><subject>Estrus</subject><subject>Female</subject><subject>Hydroxyprogesterones - biosynthesis</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Ovary - metabolism</subject><subject>Pregnancy</subject><subject>Pregnanes - biosynthesis</subject><subject>Pregnanes - pharmacology</subject><subject>Pregnenolone - biosynthesis</subject><subject>Progesterone - biosynthesis</subject><subject>Rats</subject><subject>Secretory Rate</subject><subject>Sterols - biosynthesis</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><recordid>eNqVUU2P1CAYJkazjqs_wYR48NbKWwoUD5p1o-4mm-hBvRIK1GHSKSMwszv_Xuo0Ez3KBcjz8T55H4ReAamhnDebGlrBK0Y7qEEKqHNPBHS8fniEVmfoMVoRQkQF0HVP0bOUNoQUULALdMGAdw1lK_TjdsIHfwh4F4Pdm-zDhMOAU3YxeJvwvc9rbNyUox6xdbvoUtJTxvoPNeH-iPPa4XDQ8TgL50_U-Tl6MugxuRfLfYm-f_r47fqmuvvy-fb66q4yJQivqDVCciIH0wBzHeWylU2Ja8QAlmhLW94acMYyyzogvCda9lKCbFtLGkLpJXp38t3t-62zS1C1i35bAqmgvfoXmfxa_QwHBZwzIUUxeL0YxPBr71JWW5-MG0c9ubBPqoOGU0pZIb49EU0MKUU3nIcAUXMraqPm1at59WpuRS2tqIcifvl3zLN0qaHg70_4vR_d8T-c1YevN_OL_gbCKZ5N</recordid><startdate>197111</startdate><enddate>197111</enddate><creator>HOLZBAUER, MARGARETHE</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>197111</creationdate><title>In vivo production of steroids with central depressant actions by the ovary of the rat</title><author>HOLZBAUER, MARGARETHE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4776-3dc79609fc215e8369492188c7f1d0ad3464c1ecd5d58106b0a9b991944d02033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Autopharmacology</topic><topic>Brain - drug effects</topic><topic>Chromatography, Gas</topic><topic>Chromatography, Paper</topic><topic>Estrus</topic><topic>Female</topic><topic>Hydroxyprogesterones - biosynthesis</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Ovary - metabolism</topic><topic>Pregnancy</topic><topic>Pregnanes - biosynthesis</topic><topic>Pregnanes - pharmacology</topic><topic>Pregnenolone - biosynthesis</topic><topic>Progesterone - biosynthesis</topic><topic>Rats</topic><topic>Secretory Rate</topic><topic>Sterols - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HOLZBAUER, MARGARETHE</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HOLZBAUER, MARGARETHE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo production of steroids with central depressant actions by the ovary of the rat</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1971-11</date><risdate>1971</risdate><volume>43</volume><issue>3</issue><spage>560</spage><epage>569</epage><pages>560-569</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><abstract>Summary
1
In addition to progesterone and 20‐dihydroprogesterone, the following unconjugated steroids were isolated from ovarian tissue and ovarian venous blood of mature, non‐pregnant rats: pregnenolone, 3βOH‐5α‐pregnan‐20‐one, 3αOH‐5α‐pregnan‐20‐one, 20αOH‐5α‐pregnan‐3‐one and 5α‐pregnane‐3α, 20α‐diol.
2
Their concentration in the ovarian tissue and their secretion rates into the ovarian venous blood was of the same order of magnitude as that of progesterone.
3
In the evening of the day of pro‐oestrus significant increases in the ovarian contents of the following steroids were observed: progesterone,+ 140%; 3αOH‐5α‐pregnan‐20‐one, +320%; 20αOH‐5α‐pregnan‐3‐one, +195%; sum of pregnenolone and 3βOH‐5α‐pregnan‐20‐one, +275%.
4
At the same time the ovarian progesterone secretion rate was increased by 365%, that of 3αOH‐5α‐pregnan‐20‐one by 190%.
5
A possible physiological role of the ovarian allopregnane derivatives as central depressant agents is discussed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>5168235</pmid><doi>10.1111/j.1476-5381.1971.tb07186.x</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1188 |
| ispartof | British journal of pharmacology, 1971-11, Vol.43 (3), p.560-569 |
| issn | 0007-1188 1476-5381 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1665797 |
| source | Open Access: PubMed Central |
| subjects | Animals Autopharmacology Brain - drug effects Chromatography, Gas Chromatography, Paper Estrus Female Hydroxyprogesterones - biosynthesis Hypnotics and Sedatives - pharmacology Ovary - metabolism Pregnancy Pregnanes - biosynthesis Pregnanes - pharmacology Pregnenolone - biosynthesis Progesterone - biosynthesis Rats Secretory Rate Sterols - biosynthesis |
| title | In vivo production of steroids with central depressant actions by the ovary of the rat |
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