distribution of lithium, sodium and magnesium in rat brain and plasma after various periods of administration of lithium in the diet

1 The tissue solubilizer Soluene‐100 provides an efficient and easy means of preparing small amounts of rat tissue for cation analysis. 2 Administration of lithium ions to rats for two days to 42 days by the addition of lithium chloride to the diet at a concentration of 30 mmol/kg dry weight results...

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Bibliographic Details
Published in:British journal of pharmacology 1975-02, Vol.53 (2), p.235-239
Main Authors: Bond, P.A, Brooks, B.A, Judd, A
Format: Article
Language:English
Subjects:
Animals
Brain - metabolism
Brain Chemistry
Diet
human nutrition
Lithium - metabolism
Magnesium - metabolism
Male
nutrition education
Rats
Sodium - metabolism
Time Factors
Water - metabolism
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Summary:1 The tissue solubilizer Soluene‐100 provides an efficient and easy means of preparing small amounts of rat tissue for cation analysis. 2 Administration of lithium ions to rats for two days to 42 days by the addition of lithium chloride to the diet at a concentration of 30 mmol/kg dry weight results in (a) the uniform distribution of lithium throughout the brain at a concentration comparable to that found in plasma; (b) decrease in the brain sodium concentration; (c) a decrease in brain magnesium concentration and an increase in plasma magnesium concentration; (d) no change in brain water content. 3 The inclusion of LiCl in the diet at a concentration of 30 mmol/kg dry food gives consistent and predictable plasma and brain levels of lithium in the rat without the occurrence of serious side effects over periods of up to 42 days.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1975.tb07354.x