THE EFFECTS OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE AND GUANOSINE 3′,5′‐MONOPHOSPHATE AND THEOPHYLLINE ON RENIN SECRETION IN THE ISOLATED PERFUSED KIDNEY OF THE RAT

• Published in: British journal of pharmacology 1975-05, Vol.54 (1), p.55-60
• Main Authors: PEART, W.S., QUESADA, T., TENYI, I.
• Format: Article
• Language: English
• Subjects: Animals; Biological Assay; Cyclic AMP - pharmacology; Cyclic GMP - pharmacology; Juxtaglomerular Apparatus - metabolism; Kidney - drug effects; Propranolol - pharmacology; Rats; Renin - metabolism; Theophylline - pharmacology
• ISSN: 0007-1188; 1476-5381
• DOI: 10.1111/j.1476-5381.1975.tb07409.x

1 The influence of cyclic adenosine 3′,5′‐monophosphate (cyclic AMP), cyclic guanosine 3′,5′‐monophosphate (cyclic GMP) and theophylline on renin secretion was examined in the isolated kidney of the rat perfused with Krebs dextran solution. 2 Neither cyclic AMP (10−6 to 10−4 M) nor dibutyryl cyclic AMP (10−5 M) produced an increase in renin secretion. 3 Cyclic GMP and 8 Br‐cyclic GMP caused a small rise in renin secretion in some experiments but this effect was independent of the dose and its physiological significance is uncertain. 4 Theophylline (10−6 to 10−4 M) caused a significant elevation in renin secretion which was not blocked by (+)‐propranolol. Theophylline with cyclic AMP or cyclic GMP did not produce an amplified effect. 5 Despite previous suggestions that cyclic AMP stimulated renin secretion, this could not be confirmed in the present preparation. Since there is no evidence that cyclic AMP or cyclic GMP (or their derivatives, dibutyryl cyclic AMP and 8 Br‐cyclic GMP) enter the cells, it will be necessary to study their activity in isolated juxtaglomerular cells to define a possible rǒle.