VASOCONSTRICTOR RESPONSE TO ARACHIDONIC ACID IN THE ISOLATED HIND LIMB OF THE DOG

1Arachidonic acid (AA) (25‐200 μg/kg) produced a dose‐related increase in perfusion pressure in dog isolated hind limbs perfused with either blood or a platelet‐free perfusate. 2Prostaglandin E2 produced vasodilatation while prostaglandin produced no vascular change at these administered doses. 3Phe...

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Bibliographic Details
Published in:British journal of pharmacology 1977-02, Vol.59 (2), p.269-273
Main Authors: FITZPATRICK, T.M., JOHNSON, M., KOT, P.A., RAMWELL, P.W., ROSE, J.C.
Format: Article
Language:English
Subjects:
Animals
Arachidonic Acids - pharmacology
Aspirin - pharmacology
Blood Pressure - drug effects
Dogs
Drug Interactions
Female
Hindlimb - blood supply
Indomethacin - pharmacology
Male
Norepinephrine - pharmacology
Phentolamine - pharmacology
Prostaglandins E - pharmacology
Prostaglandins F - pharmacology
Vasomotor System - drug effects
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Summary:1Arachidonic acid (AA) (25‐200 μg/kg) produced a dose‐related increase in perfusion pressure in dog isolated hind limbs perfused with either blood or a platelet‐free perfusate. 2Prostaglandin E2 produced vasodilatation while prostaglandin produced no vascular change at these administered doses. 3Phentolamine did not alter the arachidonic acid response, eliminating possible α‐adrenoceptor mediation. 4Aspirin and indomethacin blocked the vasoconstrictor response to AA. 5This study indicates that a vasoactive intermediate in prostaglandin synthesis can be elaborated in the absence of platelets.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1977.tb07489.x