TOLMESOXIDE, A DRUG THAT LOWERS BLOOD PRESSURE BY A DIRECT RELAXANT EFFECT ON VASCULAR SMOOTH MUSCLE

1 The blood pressure of conscious normotensive, deoxycorticosterone acetate (DOCA) hypertensive and 1 kidney Goldblatt hypertensive rats and renal hypertensive and normotensive cats was reduced by tolmesoxide (4,5‐dimethoxy‐o‐tolyl methyl sulphoxide). 2 Tachycardia accompanied the hypotension. In ra...

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Bibliographic Details
Published in:British journal of pharmacology 1978-05, Vol.63 (1), p.111-118
Main Author: DOXEY, J.C.
Format: Article
Language:English
Subjects:
Animals
Antihypertensive Agents
Blood Pressure - drug effects
Cats
Diuresis - drug effects
Dose-Response Relationship, Drug
Heart Rate - drug effects
Hypertension - drug therapy
Male
Propranolol - pharmacology
Rats
Sulfoxides - antagonists & inhibitors
Sulfoxides - pharmacology
Sulfoxides - therapeutic use
Toluene - analogs & derivatives
Toluene - pharmacology
Toluene - therapeutic use
Vasodilator Agents
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Summary:1 The blood pressure of conscious normotensive, deoxycorticosterone acetate (DOCA) hypertensive and 1 kidney Goldblatt hypertensive rats and renal hypertensive and normotensive cats was reduced by tolmesoxide (4,5‐dimethoxy‐o‐tolyl methyl sulphoxide). 2 Tachycardia accompanied the hypotension. In rats the increase in heart rate was abolished by concurrent administration of propranolol. Tachycardia did not occur in pithed rats. 3 Vasoconstriction induced by sympathetic stimulation, noradrenaline, tyramine, angiotensin or vasopressin was antagonized by tolmesoxide. 4 The antagonism of vasoconstrictor responses produced by tolmesoxide was unaffected by β‐adrenoceptor, muscarinic or histamine antagonists. 5 It is concluded that the lowering of pressure produced by tolmesoxide results from a direct relaxant effect on vascular smooth muscle.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1978.tb07780.x