CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE AND THE MECHANISM OF ACTION OF THREE COMMON ANTI‐INFLAMMATORY DRUGS

1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3′, 5′‐monophosphate (cyclic AMP) concentration in leucocytes during a crystal‐induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection o...

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Bibliographic Details
Published in:British journal of pharmacology 1979-02, Vol.65 (2), p.163-165
Main Authors: DEPORTER, D.A., DUNN, C.J., WILLOUGHBY, D.A.
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents - pharmacology
Colchicine - pharmacology
Cyclic AMP - blood
Dexamethasone - pharmacology
Diphosphates - pharmacology
Indomethacin - pharmacology
Leukocytes - drug effects
Leukocytes - metabolism
Male
Pleurisy - chemically induced
Pleurisy - metabolism
Rats
Time Factors
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Summary:1 The effects of indomethacin, dexamethasone and colchicine on cyclic adenosine 3′, 5′‐monophosphate (cyclic AMP) concentration in leucocytes during a crystal‐induced pleurisy in rats were studied. 2 Each of the drugs significantly increased leucocyte cyclic AMP content within 3 h of the injection of crystals. 3 By 6 h, leucocyte cyclic AMP levels were returning toward control levels and could not be sustained at the higher level by an additional administration of the respective anti‐inflammatory drug.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1979.tb07814.x