Falciparum malaria cured by quinine followed by sulfadoxine-pyrimethamine

Quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose of sulfadoxine-pyrimethamine (Fansidar) is the most effective treatment of chloroquine-resistant falciparum malaria. This regimen cured 96% of patients (302 out of 314) with an average initial parasite co...

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Bibliographic Details
Published in:BMJ 1975-04, Vol.2 (5961), p.15-17
Main Authors: Hall, A P, Doberstyn, E B, Mettaprakong, V, Sonkom, P
Format: Article
Language:English
Subjects:
Administration, Oral
Adult
Antimalarials
Blood - parasitology
Dosage
Drug Combinations
Drug Therapy, Combination
Falciparum malaria
Female
Fever
Hospital costs
Humans
Injections, Intravenous
Malaria
Malaria - drug therapy
Malaria - etiology
Malaria - parasitology
Male
Medical cures
Parasitemia
Parasites
Plasmodium falciparum - isolation & purification
Pyrimethamine - therapeutic use
Quinine - administration & dosage
Quinine - therapeutic use
Sulfadoxine - therapeutic use
Sulfanilamides - therapeutic use
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Summary:Quinine (at least four doses given at intervals of eight to 12 hours) followed by a single dose of sulfadoxine-pyrimethamine (Fansidar) is the most effective treatment of chloroquine-resistant falciparum malaria. This regimen cured 96% of patients (302 out of 314) with an average initial parasite count of 90 X 10-9/1.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5961.15