Interaction of phenytoin and primidone

The ratio of derived phenobarbitone to unmetabolized primidone in the serum was significantly higher in 50 epileptic patients on a combination of primidone and phenytoin than in 12 patients on primidone alone, though the dose and serum levels of primidone were similar in the two groups. Out of 253 p...

Full description

Saved in:
Bibliographic Details
Published in:BMJ 1975-06, Vol.2 (5971), p.594-595
Main Authors: Reynolds, E H, Fenton, G, Fenwick, P, Johnson, A L, Laundy, M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anticonvulsants
Dosage
Drug Interactions
Female
Humans
Male
Middle Aged
Neurology
Phenobarbital - blood
Phenytoin - blood
Phenytoin - metabolism
Primidone - blood
Primidone - metabolism
Seizures
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The ratio of derived phenobarbitone to unmetabolized primidone in the serum was significantly higher in 50 epileptic patients on a combination of primidone and phenytoin than in 12 patients on primidone alone, though the dose and serum levels of primidone were similar in the two groups. Out of 253 patients attending a seizure clinic 47% were taking a combination of these two anticonvulsants. The effect of phenytoin on the metabolism of primidone may have clinical implications in view of the frequency of their combined use.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5971.594