An abnormality of oestrogen feedback in amenorrhoea-galactorrhoea

Fourteen patients with amenorrhoea and hyperprolactin-anemia but no evidence of pituitary tumours were each given an intramuscular injection of 1 mg oestradiol benzoate. Thirteen patients failed to release luteinizing hormone in response to the oestrogen. This hypothalamic abnormality may help to ex...

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Bibliographic Details
Published in:BMJ 1975-08, Vol.3 (5978), p.274-275
Main Authors: Glass, M R, Shaw, R W, Butt, W R, Edwards, R L, London, D R
Format: Article
Language:English
Subjects:
Amenorrhea - physiopathology
Endocrinology
Estradiol - blood
Estradiol - pharmacology
Estrogens
Estrogens - physiology
Feedback
Female
Follicle Stimulating Hormone - blood
Galactorrhea - physiopathology
Gynecology
Hormones
Humans
Lactation Disorders - physiopathology
Luteinizing Hormone - blood
Luteinizing Hormone - metabolism
Medical journals
Medical research
Metabolic diseases
Obstetrics
Positive feedback
Pregnancy
Progesterone - blood
Prolactin - blood
Secretory Rate - drug effects
Steroids
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Summary:Fourteen patients with amenorrhoea and hyperprolactin-anemia but no evidence of pituitary tumours were each given an intramuscular injection of 1 mg oestradiol benzoate. Thirteen patients failed to release luteinizing hormone in response to the oestrogen. This hypothalamic abnormality may help to explain the menstrual disturbances in subjects with hyperprolactinaemia.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.3.5978.274