Occult pulmonary haemorrhage in leukaemia

Through gleeding into the lung parenchyma is responsible for morbidity and mortality in patients with leukaemia pulmonary haemorrhage is seldom diagnosed during life. We diagnosed occult pulmonary haemorrhage in five leukaemic patients with unexplained infiltrates on chest roetgenograms by examining...

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Bibliographic Details
Published in:BMJ 1975-04, Vol.2 (5964), p.166-168
Main Authors: Golde, D W, Drew, W L, Klein, H Z, Finley, T N, Cline, M J
Format: Article
Language:English
Subjects:
Alveolar macrophages
Autopsy
Bleeding
Bronchoalveolar lavage
Child
Clines
Disease remission
Erythrocytes
Female
Hemorrhage
Hemorrhage - diagnosis
Hemorrhage - etiology
Hemorrhage - pathology
Hemosiderin - analysis
Humans
Leukemia
Leukemia - complications
Leukemia - pathology
Lung - pathology
Lung Diseases - diagnostic imaging
Lung Diseases - etiology
Lungs
Macrophages
Macrophages - analysis
Male
Middle Aged
Radiography
Therapeutic Irrigation
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Summary:Through gleeding into the lung parenchyma is responsible for morbidity and mortality in patients with leukaemia pulmonary haemorrhage is seldom diagnosed during life. We diagnosed occult pulmonary haemorrhage in five leukaemic patients with unexplained infiltrates on chest roetgenograms by examining alveolar macrophages retrieved by bronchopulmonary lavage. Macrophage haemosiderin content was greatly increased in the patients with pulmonary haemorrhage as compared to normal and thrombocytopenic control subjects. Haemoglobin and intact erythrocytes in alveolar macrophages were taken as evidence of recent haemorrhage. Intrapulmonary bleeding may occur often in patients with leukaemia, and bronchopulmonary lavage offers a safe approach to diagnosis and allows for concomitant identification of pulmonary infection.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.2.5964.166