Diagnosis of sex in preimplantation embryos by fluorescent in situ hybridisation

Preimplantation diagnosis of sex in embryos obtained by in vitro fertilization and selective transfer of female embryos is an alternative to induced abortion of male fetuses. The application of dual color fluorescent in situ hybridization for sexing interphase nuclei of three day old human preimplan...

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Bibliographic Details
Published in:BMJ 1993-05, Vol.306 (6889), p.1382-1382
Main Authors: Griffin, D K, Wilton, L J, Handyside, A H, Atkinson, G H, Winston, R M, Delhanty, J D
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Biopsies
Chromosome disorders
Embryonic cells
Embryos
Female
Fertilization in Vitro
Fetuses
Fluorescence in situ hybridization
Genetic Diseases, Inborn - prevention & control
Genetic Linkage
Gynecology. Andrology. Obstetrics
Humans
In Situ Hybridization, Fluorescence - methods
Infants
Male
Management. Prenatal diagnosis
Medical research
Medical sciences
Pregnancy
Pregnancy Outcome
Pregnancy. Fetus. Placenta
Reproduction
Sex chromosomes
Sex Determination Analysis - methods
Sexes
X Chromosome
Zygotes
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Summary:Preimplantation diagnosis of sex in embryos obtained by in vitro fertilization and selective transfer of female embryos is an alternative to induced abortion of male fetuses. The application of dual color fluorescent in situ hybridization for sexing interphase nuclei of three day old human preimplantation embryos is examined and evaluated.
ISSN:0959-8138
0959-8146
1468-5833
1756-1833
DOI:10.1136/bmj.306.6889.1382