A breast-ovarian cancer susceptibility gene maps to chromosome 17q21

Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the locati...

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Bibliographic Details
Published in:American journal of human genetics 1993-04, Vol.52 (4), p.736-742
Main Authors: FEUNTEUN, J, NAROD, S. A, LYNCH, H. T, WATSON, P, CONWAY, T, LYNCH, J, PARBOOSINGH, J, O'CONNELL, P, WHITE, R, LENOIR, G. M
Format: Article
Language:English
Subjects:
Adult
Aged
BASIC BIOLOGICAL SCIENCES
Biological and medical sciences
BIOLOGICAL VARIABILITY
BODY
breast
Breast Neoplasms - genetics
Canada
carcinoma
chromosome 17
Chromosome Mapping - methods
CHROMOSOMES
Chromosomes, Human, Pair 17
DISEASES
Family Health
Female
FEMALE GENITALS
Gene Expression
Genes, Dominant
Genetic Linkage
GENETIC MAPPING
Genetic Markers
Genetic Predisposition to Disease
GENETIC VARIABILITY
Genotype
GLANDS
GONADS
Gynecology. Andrology. Obstetrics
HUMAN CHROMOSOME 17
HUMAN CHROMOSOMES
Humans
Lod Score
Male
Mammary gland diseases
MAMMARY GLANDS
man
MAPPING
Medical sciences
Middle Aged
NEOPLASMS
Neoplastic Syndromes, Hereditary
NORTH AMERICA
ORGANS 550400 > Genetics
Ovarian Neoplasms - genetics
OVARIES
Pedigree
Polymorphism, Genetic
Proto-Oncogenes
Recombination, Genetic
restriction fragment length polymorphism
RFLPS
Tumors
United States
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Summary:Nineteen North American Caucasian families that contain a minimum of four confirmed cases of breast or ovarian cancer have been studied. Four polymorphisms (cLB17.1, D17S579, D17S588, and D17S74), which span a region of approximately 15 cM on chromosome 17q12, were typed. Our data confirm the location of a dominant gene conferring susceptibility to breast and ovarian cancer (maximum lod = 9.78) and suggest that the breast-ovarian cancer syndrome is genetically heterogeneous. Two recombinants in one large family suggest that the breast-ovarian cancer locus lies between D17S588 and D17S579.
ISSN:0002-9297
1537-6605